drugset / Trial / NCT00744328
Postpartum Depression: Transdermal Estradiol Versus Sertraline
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to determine whether estrogen patches are effective for the treatment of postpartum major depression, as compared to sertraline (Zoloft) and placebo.
Timeline
- Start
- 2008-08
- Primary completion
- 2013-09
- Completion
- 2013-09
Publications
- Pulido CM, Walson IS, Yang A, Stika CS, Sit DK, Wisner KL. Differentiating Depressive Symptoms From Side Effects in Individuals With Major Depressive Disorder With Postpartum Onset. J Clin Psychopharmacol. 2025 Mar-Apr 01;45(2):106-110. doi: 10.1097/JCP.0000000000001928. Epub 2024 Dec 4.
- Prairie BA, Wisniewski SR, Luther JF, Sit D, Wisner KL. Postpartum lipid levels in women with major depression. J Womens Health (Larchmt). 2012 May;21(5):534-8. doi: 10.1089/jwh.2011.3256. Epub 2012 Jan 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Estradiol | Other / unclassified | 50 ug | Other |
| Subject | Estradiol | Other / unclassified | 200 ug | Other |
| Comparator | Sertraline | Small molecule | 50 mg | Oral |
| Comparator | Sertraline | Small molecule | 200 mg | Oral |