drugset / Trial / NCT00767117
TMC125-TiDP2-C197: A Phase I Trial to Investigate the Pharmacokinetic Interaction Between Lopinavir/Ritonavir and TMC125 Both at Steady-state in Healthy Volunteers.
RandomizedCrossoverOpen-labelTreatment
Summary
The purpose of the study is to determine the effect of steady-state concentrations of LPV, co-administered with a low dose of ritonavir, on the steady-state pharmacokinetics of TMC125 and to determine the effect of steady-state concentrations of TMC125 on the steady-state pharmacokinetics of LPV, co-administered with a low dose of ritonavir.
Timeline
- Start
- 2008-09
- Primary completion
- 2008-12
- Completion
- 2008-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Etravirine | Small molecule | 200 mg | — |
| Subject | Lopinavir | Other / unclassified | 400 mg | — |
| Subject | Ritonavir | Other / unclassified | 100 mg | — |