Active Screening of Latent TB Infection, Treatment and Long Term Follow-up in Prison

NCT00767975 ↗

Phase 3 Completed 2384 enrolled National Taiwan University Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

LTBI Treatment is effective in prison

Timeline

Start: 2008-01
Primary completion: 2010-11
Completion: 2010-11

Outcome

Met primary endpoint

paper The 4R group (n = 190) was less likely to experience an adverse event leading to discontinuation of treatment (2% vs. 12%, P < 0.001 PMID 22410137 ↗

Publications

Chan PC, Yang CH, Chang LY, Wang KF, Lu BY, Lu CY, Shao PL, Hsueh PR, Fang CT, Huang LM. Latent tuberculosis infection treatment for prison inmates: a randomised controlled trial. Int J Tuberc Lung Dis. 2012 May;16(5):633-8. doi: 10.5588/ijtld.11.0504. Epub 2012 Mar 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Isoniazid	Small molecule	300 mg	—
Subject	Rifampicin	Small molecule	600 mg	—