The Effects of Pentoxifylline on PAI-1 in an Obese Population

Summary

PAI-1 is elevated in obese individuals. TNF-alpha, an inflammatory mediator is believed to play a role in obesity mediated elevations in PAI-1 levels. TNF-alpha blockade with antibodies and the drug pentoxifylline have been shown to lower PAI-1 levels in animal models. This study tests the hypothesis that pentoxifylline will lower PAI-1 levels in human subjects.

Timeline

Start

2003-05

Primary completion

2009-05

Completion

2009-06

Drugs

Indications