drugset / Trial / NCT00779792
Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation
Phase 4
Unknown
36 enrolled
Odense University Hospital
LEO Pharma · collabUniversity of Southern Denmark · collab
NaSingle-groupTriple-blindTreatment
Summary
The purpose of this study is to compare the efficacy of glycerol ointment, triamcinolone acetonide ointment, clobetasol ointment and tacrolimus ointment on irritated skin in a cumulative skin irritation test model using healthy volunteers.
Timeline
- Start
- 2008-09
- Primary completion
- 2008-11
- Completion
- 2008-11
Publications
- Background Andersen F, Hedegaard K, Petersen TK, Bindslev-Jensen C, Fullerton A, Andersen KE. Comparison of the effect of glycerol and triamcinolone acetonide on cumulative skin irritation in a randomized trial. J Am Acad Dermatol. 2007 Feb;56(2):228-35. doi: 10.1016/j.jaad.2006.08.063. Epub 2006 Dec 6.
- Background Schliemann S, Kelterer D, Bauer A, John SM, Skudlik C, Schindera I, Wehrmann W, Elsner P. Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis. Contact Dermatitis. 2008 May;58(5):299-306. doi: 10.1111/j.1600-0536.2007.01314.x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clobetasol | Small molecule | 0.5 mg | Topical |
| Subject | Glycerol | Small molecule | 0.5 mg | Topical |
| Subject | Tacrolimus | Small molecule | 0.5 mg | Topical |
| Subject | Triamcinolone Acetonide | Other / unclassified | 0.5 mg | — |