Intraoperative Glucose Control in Liver Transplant
Summary
The goal of the proposed study is to evaluate the effectiveness of intraoperative, strict glycemic control to improve survival and infection rates following liver transplantation in a randomized, prospective trial.Primary objective: To determine if strict intraoperative blood glucose control, when compared to standard intraoperative glycemic control, improves 1-year recipient survival and decreases surgical complications, including infections, following liver transplantation.
Timeline
- Start
- 2008-07
- Primary completion
- 2009-09
- Completion
- 2009-09
Outcome
Missed primary endpoint
registry analysis (superiority or other test); Strict Glycemic Control vs Standard of Care Control; p = 0.999; Fisher Exact NCT00780026 ↗
paper There was no statistically significant difference in patient survival between conventional and strict control respectively;1 year, 88% vs 88% (p-0.99) PMID 31901245 ↗
registry analysis (superiority or other test); Strict Glycemic Control vs Standard of Care Control; p = 0.841; Chi-squared; note: P value for Bacterial infection NCT00780026 ↗
registry analysis (superiority or other test); Strict Glycemic Control vs Standard of Care Control; p = 0.298; Chi-squared; note: P-value for fungal infection NCT00780026 ↗
registry analysis (superiority or other test); Strict Glycemic Control vs Standard of Care Control; p = 0.585; Chi-squared; note: P value for transplant incision wound NCT00780026 ↗
registry analysis (superiority or other test); Strict Glycemic Control vs Standard of Care Control; p = 0.505; Chi-squared; note: P value for viral infection NCT00780026 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Insulin | Protein / enzyme biologic | — | — |
Indications
No indication recorded.