Training Effects on Skeletal Muscle Fatty Acid Metabolism
Summary
We are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. We know that if pharmaceutical grade fat is infused into people, they develop insulin resistance. Likewise, we would like to infuse pharmaceutical grade fat into trained subjects, believing that trained subjects will have less insulin resistance, less decline in muscle energy function, and less accumulation of fat metabolites than untrained subjects. For comparing the effects of the pharmaceutical grade fat infusion, we will also have a group of trained and untrained subjects given a control (glycerol) infusion. Glycerol is basically the same as pharmaceutical grade fat infusion without the fat component.
Timeline
- Start
- 2009-01
- Primary completion
- 2014-01
- Completion
- 2014-01
Outcome
Missed primary endpoint
registry MEAN Lipid Trained: 8 (Standard Deviation 3) M value NCT00786487 ↗
registry MEAN Glycerol Trained: 12 (Standard Deviation 2) M value NCT00786487 ↗
registry analysis (superiority or other test); Lipid Trained vs Glycerol Trained; p <0.05; t-test, 2 sided NCT00786487 ↗
registry MEAN Lipid Untrained: 6 (Standard Deviation 2) M value NCT00786487 ↗
registry MEAN Glycerol Untrained: 11 (Standard Deviation 4) M value NCT00786487 ↗
registry analysis (superiority or other test); Lipid Untrained vs Glycerol Untrained; p <0.05; t-test, 2 sided NCT00786487 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Glycerol | Small molecule | 2.25 g | — |
| Subject | Intralipid | Other / unclassified | 20 % | — |
Indications
No indication recorded.