Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis

Phase 3 Completed 30 enrolled National University of La Plata Clínica Bazterrica · collab National Agency for Scientific and Technological Promotion, Argentina · collab Sanatorio Otamendi y Miroli · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Fluid resuscitation of severe sepsis may consist of natural or artificial colloids or crystalloids. There is no evidence-based support for one type of fluid over another. The investigators hypothesis is that fluid resuscitation with Voluven® is advantageous to normal saline solution to improve sublingual microcirculation.

Timeline

Start: 2006-01
Primary completion: 2009-08
Completion: 2009-08

Publications

Dubin A, Pozo MO, Casabella CA, Murias G, Palizas F Jr, Moseinco MC, Kanoore Edul VS, Palizas F, Estenssoro E, Ince C. Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients. J Crit Care. 2010 Dec;25(4):659.e1-8. doi: 10.1016/j.jcrc.2010.04.007. Epub 2010 Sep 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Volulyte	Other / unclassified	6 %	—
Comparator	sodium chloride	Unknown	—	—

Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis

Summary

Timeline

Publications

Drugs

Indications