Spinal Mepivicaine With Fentanyl for Outpatient Knee Arthroscopy

Completed 34 enrolled University Health Network, Toronto

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to determine if the addition of intrathecal fentanyl to low dose mepivacaine spinal anesthesia provides adequate surgical anesthesia with shorter duration of motor blockade. It is hypothesized that lower doses of spinal mepivacaine when combined with fentanyl will result in adequate surgical block for knee arthroscopy surgery with faster recovery and discharge compared to mepivacaine alone.

Timeline

Start: 2008-08
Primary completion: 2009-05
Completion: 2009-05

Publications

O'Donnell D, Manickam B, Perlas A, Karkhanis R, Chan VW, Syed K, Brull R. Spinal mepivacaine with fentanyl for outpatient knee arthroscopy surgery: a randomized controlled trial. Can J Anaesth. 2010 Jan;57(1):32-8. doi: 10.1007/s12630-009-9207-6. Epub 2009 Oct 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	10 ug	Intrathecal
Subject	Mepivacaine	Other / unclassified	30 mg	Intrathecal
Subject	Mepivacaine	Other / unclassified	45 mg	Intrathecal

Indications

No indication recorded.