Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED)

Summary

This study will examine the effect of statin and niacin therapy on carotid plaque biomarkers

Timeline

Start

2009-04

Primary completion

2010-10

Completion

2010-10

Outcome

Missed primary endpoint

registry Statin 80 mg + Niacin Extended-release (ER) vs Statin 10 mg; p = 0.811; Least Square Mean Difference 0.27 (90% CI -0.24 to 0.78); ANOVA NCT00804843 ↗

registry Statin 80 mg + Niacin Extended-release (ER) vs Statin 10 mg; p = 0.898; Least Square Mean Difference 3.64 (90% CI -1.09 to 8.36); ANOVA NCT00804843 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	10 mg	—
Subject	Atorvastatin	Small molecule	80 mg	—
Subject	Niacin	Small molecule	2 g	—
Comparator	Simvastatin	Small molecule	10 mg	—
Comparator	Simvastatin	Small molecule	80 mg	—

Indications