drugset / Trial / NCT00806585

Dose-ranging Study to Evaluate the Effectiveness and Tolerability of MK0736 in Patients With Type 2 Diabetes Mellitus (T2DM) and Hypertension (0736-007)

NCT00806585

Phase 2 Terminated 620 enrolled Merck Sharp & Dohme LLC
RandomizedParallel-groupDouble-blindTreatment

Summary

The study will assess the efficacy and tolerability of MK0736 in patients with Type 2 Diabetes Mellitus and Hypertension who are on ongoing therapy with Angiotensin-Converting Enzyme or Angiotensin Receptor Blocker. After a 3 to 5 week pre-randomization phase, patients will be randomized to either MK0736 (3 doses), placebo, or hydrochlorothiazide (HCTZ). The study will also include a 3 week, posttreatment follow-up period.

Timeline

Start
2008-12
Primary completion
2010-03
Completion
2010-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Hydrochlorothiazide Unknown 12.5 mg Oral
Subject MK-0736 Small molecule 0.5 mg Oral
Subject MK-0736 Small molecule 2 mg Oral
Subject MK-0736 Small molecule 8 mg Oral