drugset / Trial / NCT00806585
Dose-ranging Study to Evaluate the Effectiveness and Tolerability of MK0736 in Patients With Type 2 Diabetes Mellitus (T2DM) and Hypertension (0736-007)
RandomizedParallel-groupDouble-blindTreatment
Summary
The study will assess the efficacy and tolerability of MK0736 in patients with Type 2 Diabetes Mellitus and Hypertension who are on ongoing therapy with Angiotensin-Converting Enzyme or Angiotensin Receptor Blocker. After a 3 to 5 week pre-randomization phase, patients will be randomized to either MK0736 (3 doses), placebo, or hydrochlorothiazide (HCTZ). The study will also include a 3 week, posttreatment follow-up period.
Timeline
- Start
- 2008-12
- Primary completion
- 2010-03
- Completion
- 2010-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydrochlorothiazide | Unknown | 12.5 mg | Oral |
| Subject | MK-0736 | Small molecule | 0.5 mg | Oral |
| Subject | MK-0736 | Small molecule | 2 mg | Oral |
| Subject | MK-0736 | Small molecule | 8 mg | Oral |