Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy

Completed 251 enrolled Brigham and Women's Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to evaluate if post-operative antibiotic prophylaxis decreases infectious complications when compared to pre-operative antibiotics alone, in patients undergoing elective thoracic surgery requiring tube thoracostomy (chest tube).

Timeline

Start: 2008-03
Primary completion: 2011-04
Completion: 2011-04

Publications

Oxman DA, Issa NC, Marty FM, Patel A, Panizales CZ, Johnson NN, Licona JH, McKenna SS, Frendl G, Mentzer SJ, Jaklitsch MT, Bueno R, Colson Y, Swanson SJ, Sugarbaker DJ, Baden LR. Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg. 2013 May;148(5):440-6. doi: 10.1001/jamasurg.2013.1372.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cefazolin	Small molecule	1 g	Intravenous
Comparator	Cefazolin	Small molecule	2 g	Intravenous
Comparator	Vancomycin	Other / unclassified	1 g	Intravenous

Indications

No indication recorded.