Cefazolin

also known as Ancef · Cefamezin · cefazolin sodium · cephazolin · Cefazoline · 46083 · Acef · Cefacidal · +19 more

Developed for: skin infection · infectious disease · obesity disorder · pregnancy disorder · staphylococcus aureus infection · appendicitis · cellulitis · chronic ulcer of skin
+36 more
· endometritis · peritonitis · puerperal infection · bacterial infectious disease · breast disorder · cervical incompetence · disease of the tendon · empyema · gram-positive bacterial infections · infectious disease with sepsis · infectious peritonitis · larynx cancer · methicillin-resistant staphylococcus aureus infectious disease · methicillin-susceptible staphylococcus aureus infectious disease · neonatal sepsis · nosocomial infection · parathyroid gland disorder · periprosthetic joint infection · pneumonia · prostate cancer · prosthesis-related infectious disease · thyroid gland disorder · ulcer of lower limbs · abscess · acute endophthalmitis · bacterial arthritis · craniofacial and skeletal defects · hemopneumothorax · infectious disorder of the nervous system · infective arthritis · keratitis · osteomyelitis · preterm premature rupture of the membranes · primary bacterial infectious disease · skin disease caused by bacterial infection · staphylococcal infection
Investigated by: Radboud University Medical Center · B. Braun Medical SA · Chinese University of Hong Kong · Duke University · HaEmek Medical Center, Israel · Hamilton Health Sciences Corporation
+107 more
· Helwan University · Menzies School of Health Research · Monash University · Sonescence, Inc. · Tan Tock Seng Hospital · The Methodist Hospital Research Institute · The Physicians' Services Incorporated Foundation · The University of Queensland · University of British Columbia · University of California, Irvine · University of Florida · University of Oklahoma · West Virginia University · ANZCA CTN · Aalborg University Hospital · Aarhus University Hospital · Abdul El-Rabbany · Al-Gumhori Teaching Hospital · Aleppo University Hospital Resident Team · American Association of Hip and Knee Surgeons · Aotearoa Clinical Trials · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Aultman Health Foundation · Australasian Kidney Trials Network · Australasian Society for Infectious Diseases · Baxter Healthcare Corporation · Berry Consultants · CHU de Quebec-Universite Laval · CR-CSSS Champlain-Charles-Le Moyne · Canadian Critical Care Trials Group · Canadian Institutes of Health Research (CIHR) · Carmel Medical Center · Case Western Reserve University · Cedars-Sinai Medical Center · Chulalongkorn University · Daniela Francescato Veiga · Dartmouth-Hitchcock Medical Center · Drexel University · Esbjerg Hospital - University Hospital of Southern Denmark · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Federal University of Pernambuco · German Research Foundation · Heinrich-Heine University, Duesseldorf · Herlev and Gentofte Hospital · Hospital Italiano de Buenos Aires · Intermountain Health Care, Inc. · Ito Hospital · King's College London · Massachusetts General Hospital · Mbarara University of Science and Technology · McGill University Health Centre/Research Institute of the McGill University Health Centre · Medical College of Wisconsin · Medical University of South Carolina · Medstar Health Research Institute · Meir Medical Center · MemorialCare · MemorialCare Health System · Michael Stitely · Mikkel Herly · Minia University Hospital · Monash Medical Centre · Nantes University Hospital · National Institute of Allergy and Infectious Diseases (NIAID) · Northwestern University · Odense University Hospital · Orthopedic Research and Education Foundation · Parexel · Pfizer · Phillip Brian Smith · Post Graduate Institute of Medical Education and Research, Chandigarh · Queensland University of Technology · Rambam Health Care Campus · Rutgers, The State University of New Jersey · all 113 on the full record

Regulatory milestones approvals, filings & regulatory actions · 10 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansions (2)	US (FDA)	CEFAZOLIN SODIUM	—	2024-12-18 – 2026-02-13	fda.gov ↗
Label expansions (4)	US (FDA)	CEFAZOLIN AND DEXTROSE	—	2012-01-13 – 2024-08-26	fda.gov ↗
Label expansions (3)	US (FDA)	CEFAZOLIN IN DEXTROSE	—	2021-02-01 – 2024-05-31	fda.gov ↗
Approved	US (FDA)	ANCEF	—	1973-10-04	fda.gov ↗

Trials 80 · started per year

today

US approved 1973

197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 03 trials
Phase 0	NCT06710977	Jan 2022 → Sep 2024	cataract	Tan Tock Seng Hospital	Completed	No outcome recorded
Phase 0	NCT03853096	Apr 2019 → Apr 2020	—	University of British Columbia	Unknown	No outcome recorded
Phase 0	NCT03801252	Dec 2018 → Jun 2021	obesity disorder	University of Oklahoma	Completed	No outcome recorded
Phase 17 trials
Phase 1	NCT05205486	Apr 2022 → Jul 2023	infectious disease	B. Braun Medical SA	Completed	No outcome recorded
Phase 1	NCT05309304	Feb → Aug 2022	—	Baxter Healthcare Corporation	Completed	No outcome recorded
Phase 1	NCT03672149	Jul 2019 → Dec 2022	—	Drexel University	Unknown	No outcome recorded
Phase 1	NCT05367479	Jul 2018 → Jan 2020	hypertensive disorder, morbid obesity	Medical College of Wisconsin	Completed	No outcome recorded
Phase 1	NCT01904500	Aug 2013 → Apr 2014	obesity disorder, pregnancy disorder	University of Pittsburgh	Completed	No outcome recorded
Phase 1	NCT00850122	Jul 2013 → Jul 2018	infectious disease with sepsis	Phillip Brian Smith	Completed	No outcome recorded
Phase 1	NCT01121354	Dec 2009 → Feb 2010	infectious disease	B. Braun Medical SA	Completed	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT06640491	May 2025 → Dec 2030 expected	—	The Methodist Hospital Research Institute	Recruiting	No outcome recorded
Phase 27 trials
Phase 2	NCT06406114	May 2025 → Jul 2028 expected	anaphylaxis, drug allergy, drug pseudoallergy	Massachusetts General Hospital	Recruiting	No outcome recorded
Phase 2	NCT06488781	Apr 2025 → Dec 2028 expected	pregnancy disorder	University of Oklahoma	Recruiting	No outcome recorded
Phase 2	NCT06327113	May 2024 → May 2027 expected	chronic ulcer of skin	University of California, Los Angeles	Recruiting	No outcome recorded
Phase 2	NCT06355115	Sep 2023 → Sep 2024	—	University of Brawijaya	Unknown	No outcome recorded
Phase 2	NCT03732365	Feb 2019 → Jan 2020	chronic ulcer of skin	Sonescence, Inc.	Unknown	No outcome recorded
Phase 2	NCT03578965	Jul 2018 → Nov 2021	low grade vulvar intraepithelial neoplasia, vulvar benign neoplasm	Washington University School of Medicine	Completed	No outcome recorded
Phase 2	NCT00438269	Feb 2003 → Mar 2005	nosocomial infection, pneumonia	Canadian Critical Care Trials Group	Completed	No outcome recorded
Phase 313 trials
Phase 3	NCT06576154	Aug 2024 → Aug 2025 overdue	skin infection	University of Aleppo	Recruiting	No outcome recorded
Phase 3	NCT04731025	Jan 2021 → Feb 2027 expected	breast disorder, poisoning, prosthesis-related infectious disease	Mikkel Herly	Recruiting	No outcome recorded
Phase 3	NCT06402591	Jan 2019 → Dec 2023	periprosthetic joint infection	Radboud University Medical Center	Unknown	No outcome recorded
Phase 3	NCT03046511	Mar 2017 → Dec 2023	infectious peritonitis	Carmel Medical Center	Unknown	No outcome recorded
Phase 3	NCT02838940	Aug 2016 → Aug 2019	—	Tel-Aviv Sourasky Medical Center	Unknown	No outcome recorded
Phase 3	NCT02365493	Aug 2015 → Oct 2018	methicillin-resistant staphylococcus aureus infectious disease	Menzies School of Health Research	Terminated	No outcome recorded
Phase 3	NCT03862170	Feb 2015 → Feb 2020	prostate cancer	CR-CSSS Champlain-Charles-Le Moyne	Terminated	No outcome recorded
Phase 3	NCT01792804	Dec 2013 → Mar 2020	staphylococcus aureus infection	Heinrich-Heine University, Duesseldorf	Completed	No outcome recorded
Phase 3	NCT00811603	Aug 2008 → Jun 2009	infectious disease	MemorialCare	Completed	No outcome recorded
Phase 3	NCT01867138	Mar 2007 → Aug 2010	neonatal sepsis	Hospital Italiano de Buenos Aires	Completed	No outcome recorded
Phase 3	NCT00108433	Sep 2005 → Sep 2006	gram-positive bacterial infections	Pfizer	Terminated	No outcome recorded
Phase 3	NCT00467948	Jun 2004 → Mar 2006	larynx cancer	Tehran University of Medical Sciences	Completed	No outcome recorded
Phase 3	NCT00323219	Jan 2004 → Dec 2012	cellulitis	University of British Columbia	Completed	No outcome recorded

Phase 426 trials
Phase 4	NCT07658378	Jul → Sep 2026 expected	—	Helwan University	Not yet recruiting	No outcome recorded
Phase 4	NCT07655596	Jul → Sep 2026 expected	—	Helwan University	Not yet recruiting	No outcome recorded
Phase 4	NCT06567808	Mar 2026 → Apr 2028 expected	skin infection	Hamilton Health Sciences Corporation	Not yet recruiting	No outcome recorded
Phase 4	NCT07376889	Feb 2026 → Jan 2029 expected	staphylococcus aureus infection	Intermountain Health Care, Inc.	Not yet recruiting	No outcome recorded
Phase 4	NCT07549542	Oct 2025 → Oct 2026 expected	—	Rutgers, The State University of New Jersey	Enrolling by invitation	No outcome recorded
Phase 4	NCT07148960	Sep 2025 → Jul 2027 expected	staphylococcus aureus infection	West Virginia University	Enrolling by invitation	No outcome recorded
Phase 4	NCT06920147	May 2025 → Mar 2027 expected	—	The University of Texas Health Science Center, Houston	Not yet recruiting	No outcome recorded
Phase 4	NCT06607887	Aug → Nov 2024 overdue	skin infection	Minia University Hospital	Recruiting	No outcome recorded
Phase 4	NCT05852158	Jan 2024 → Jan 2027 expected	—	Abdul El-Rabbany	Recruiting	No outcome recorded
Phase 4	NCT06093269	Nov 2023 → Dec 2025 overdue	bacterial infectious disease	University Hospital, Tours	Active not recruiting	No outcome recorded
Phase 4	NCT05447559	Feb 2023 → Dec 2027 expected	—	Monash University	Recruiting	No outcome recorded
Phase 4	NCT05137119	Feb 2022 → Dec 2028 expected	staphylococcus aureus infection	University of Melbourne	Recruiting	No outcome recorded
Phase 4	NCT03675854	Jan → Sep 2019	peritonitis	Chinese University of Hong Kong	Withdrawn	No outcome recorded
Phase 4	NCT04516148	May 2018 → Oct 2020	skin infection	Medstar Health Research Institute	Completed	No outcome recorded
Phase 4	NCT03478163	Mar 2018 → May 2021	endometritis, obstetric disorder	Cedars-Sinai Medical Center	Terminated	No outcome recorded
Phase 4	NCT03283878	Oct 2017 → Nov 2024	osteoarthritis, knee	Duke University	Completed	No outcome recorded
Phase 4	NCT02593201	Feb 2016 → Dec 2018	—	Chinese University of Hong Kong	Completed	No outcome recorded
Phase 4	NCT02446782	Jan 2015 → Apr 2016	empyema, pleurisy	Post Graduate Institute of Medical Education and Research, Chandigarh	Completed	No outcome recorded
Phase 4	NCT02049944	Aug 2013 → Sep 2014	morbid obesity, pregnancy disorder, puerperal infection	MemorialCare Health System	Completed	No outcome recorded
Phase 4	NCT01899781	Aug 2013 → Jan 2015	disease of the tendon	HaEmek Medical Center, Israel	Completed	No outcome recorded
Phase 4	NCT01537380	Mar 2012 → Apr 2015	—	Nantes University Hospital	Completed	No outcome recorded
Phase 4	NCT01458223	Oct 2011 → Aug 2018	—	The London Spine Centre	Completed	No outcome recorded
Phase 4	NCT01845363	Jun → Oct 2011	obesity disorder	Federal University of Pernambuco	Completed	No outcome recorded
Phase 4	NCT01880112	Jun 2011 → Jun 2013	infectious disease	West Virginia University	Withdrawn	No outcome recorded
Phase 4	NCT01755026	Nov 2010 → Jul 2011	obesity disorder, skin infection	Michael Stitely	Completed	No outcome recorded
Phase 4	NCT00550290	Oct 2007 → Apr 2009	skin infection	Aultman Health Foundation	Completed	No outcome recorded

Phase not applicable22 trials
—	NCT07043855	May 2026 → Oct 2028 expected	infectious disease	Asan Medical Center	Enrolling by invitation	No outcome recorded
—	NCT05304871	Jan 2024 → Mar 2027	—	Dartmouth-Hitchcock Medical Center	Withdrawn	No outcome recorded
—	NCT07111702	Oct 2023 → May 2024	—	Sana'a University	Completed	No outcome recorded
—	NCT04763486	Mar 2021 → Mar 2022	puerperal infection	Meir Medical Center	Unknown	No outcome recorded
—	NCT04079686	Aug 2019 → Oct 2024	skin infection	Daniela Francescato Veiga	Completed	No outcome recorded
—	NCT06030713	Mar 2019 → Oct 2022	poisoning	University Medical Center Groningen	Completed	No outcome recorded
—	NCT03248063	Sep 2018 → Feb 2024	methicillin-susceptible staphylococcus aureus infectious disease	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
—	NCT03742908	Jun 2018 → Oct 2021	breast neoplasm	Tianjin Medical University Cancer Institute and Hospital	Unknown	No outcome recorded
—	NCT04818931	Apr 2018 → Jun 2019	breast cancer	CHU de Quebec-Universite Laval	Completed	No outcome recorded
—	NCT03595852	Mar → Sep 2018	—	University of Rwanda	Completed	No outcome recorded
—	NCT03518463	Jun → Jul 2017	pregnancy disorder	Mbarara University of Science and Technology	Completed	No outcome recorded
—	NCT02285140	Apr 2015 → Mar 2025	—	Hamilton Health Sciences Corporation	Terminated	No outcome recorded
—	NCT02404064	Mar 2015	appendicitis	HaEmek Medical Center, Israel	Unknown	No outcome recorded
—	NCT02368015	Dec 2014 → Dec 2015	—	Radboud University Medical Center	Completed	No outcome recorded
—	NCT02216227	Apr 2014 → Feb 2021	—	VA Office of Research and Development	Completed	No outcome recorded
—	NCT01810354	Apr 2013 → Jul 2014	—	Women and Infants Hospital of Rhode Island	Completed	No outcome recorded
—	NCT01785641	Dec 2012 → Dec 2013	peritonitis	Chulalongkorn University	Completed	No outcome recorded
—	NCT01420367	Nov 2011 → Nov 2013	appendicitis	Monash University	Completed	No outcome recorded
—	NCT01805856	Nov 2010 → May 2012	parathyroid gland disorder, thyroid gland disorder	Ito Hospital	Completed	No outcome recorded
—	NCT01114516	Mar 2010 → Mar 2013	cervical incompetence	Northwestern University	Completed	No outcome recorded
—	NCT00805545	Nov 2008 → Nov 2009	infectious disease	University of Florida	Completed	No outcome recorded
—	NCT00330278	Jan 2003 → Jan 2006	endometritis, skin infection	Medical University of South Carolina	Completed	No outcome recorded

Phase not stated1 trial
—	NCT01238276	—	cellulitis, ulcer of lower limbs	Sonescence, Inc.	No longer available	No outcome recorded

Also used as a comparator or background therapy in 101 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT05849090 Comparator	Mar 2023 → Dec 2024	infectious disease	University of Utah	Completed	No outcome recorded
Phase 13 trials
Phase 1	NCT04875728 Comparator	Sep 2020 → Feb 2027 expected	cutaneous melanoma	M.D. Anderson Cancer Center	Active not recruiting	No outcome recorded
Phase 1	NCT03213249 Comparator	Jul 2017 → Sep 2018	breast disorder	Washington University School of Medicine	Completed	No outcome recorded
Phase 1	NCT01904357 Comparator	Mar → Aug 2013	infectious disease	B. Braun Medical SA	Completed	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT03502356 Comparator	Apr → Jun 2018	—	Ain Shams University	Unknown	No outcome recorded
Phase 1/2	NCT03466645 Comparator	Apr 2018 → Apr 2019	—	Isfahan University of Medical Sciences	Unknown	No outcome recorded
Phase 1/2	NCT02493894 Background	Jul 2014 → May 2015	—	Isfahan University of Medical Sciences	Completed	No outcome recorded
Phase 26 trials
Phase 2	NCT07308938 Background	Oct 2026 → Dec 2029 expected	corneal ulcer	Vishal Jhanji	Not yet recruiting	No outcome recorded
Phase 2	NCT05655091 Comparator	Oct 2023 → Dec 2025 overdue	staphylococcus aureus infection	University Hospital, Basel, Switzerland	Recruiting	No outcome recorded
Phase 2	NCT05162625 Comparator	Dec 2021 → Dec 2022	acute endophthalmitis	University of Campinas, Brazil	Unknown	No outcome recorded
Phase 2	NCT04775953 Comparator	Apr 2021 → Oct 2023	staphylococcal infection	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 2	NCT01756924 Comparator	Dec 2012 → Jul 2014	periprosthetic joint infection	Arrevus Inc.	Terminated	No outcome recorded
Phase 2	NCT01029782 Comparator	May 2010 → Oct 2014	cellulitis	Kelowna General Hospital	Completed	No outcome recorded

Phase 2/34 trials
Phase 2/3	NCT03226626 Background	Dec 2021 → Jan 2022	infectious disease with sepsis, thrombotic disease	HK Surgical, Inc.	Unknown	No outcome recorded
Phase 2/3	NCT02503904 Comparator	Oct 2015 → Jun 2019	venous thromboembolism	Klein, Jeffrey A., M.D.	Unknown	No outcome recorded
Phase 2/3	NCT01400867 Comparator	Dec 2011 → May 2014	primary bacterial infectious disease	Forest Laboratories	Completed	No outcome recorded
Phase 2/3	NCT01127880 Comparator	Jul 2005 → Dec 2009	hemopneumothorax	St. Luke's Hospital, Pennsylvania	Completed	No outcome recorded
Phase 314 trials
Phase 3	NCT06336824 Comparator	Jun 2024 → May 2025 overdue	staphylococcus aureus infection	Clinical Research Centre, Malaysia	Recruiting	No outcome recorded
Phase 3	NCT04292054 Comparator	Oct 2020 → Apr 2026 overdue	—	Assistance Publique - Hôpitaux de Paris	Recruiting	No outcome recorded
Phase 3	NCT03176134 Comparator	Jan 2019 → Jul 2023	—	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 3	NCT02717871 Comparator	Mar 2016 → Oct 2020	keratitis	University Hospital, Geneva	Completed	No outcome recorded
Phase 3	NCT02344511 Comparator	Mar 2016 → Oct 2018	osteomyelitis	Durata Therapeutics International BV (an Affiliate of Actavis, Inc.)	Withdrawn	No outcome recorded
Phase 3	NCT02276482 Comparator	Mar 2015 → Sep 2018	skin disease caused by bacterial infection, skin infection	Merck & Co., Inc.	Completed	No outcome recorded
Phase 3	NCT02208063 Comparator	Dec 2014 → Apr 2018	bacterial infectious disease	Cumberland Pharmaceuticals	Terminated	No outcome recorded
Phase 3	NCT02579161 Comparator	Sep 2014 → Mar 2018	urolithiasis	Northwell Health	Completed	No outcome recorded
Phase 3	NCT01479283 Comparator	Jan 2013 → Mar 2021	bone neoplasm, infectious disease	McMaster University	Completed	No outcome recorded
Phase 3	NCT01503606 Comparator	Oct 2011 → Dec 2020	preterm premature rupture of the membranes	Samsung Medical Center	Completed	No outcome recorded
Phase 3	NCT01002911 Background	Dec 2009 → Jan 2012	cardiac rhythm disease	Population Health Research Institute	Completed	No outcome recorded
Phase 3	NCT00867295 Comparator	Sep 2008 → Dec 2009	neoplasm	Istanbul University	Completed	No outcome recorded
Phase 3	NCT00636831 Comparator	Jul 2007 → Jan 2012	—	Nihon University	Completed	No outcome recorded
Phase 3	NCT01401179 Comparator	Apr 2005 → Apr 2010	preterm premature rupture of the membranes	Samsung Medical Center	Completed	No outcome recorded

Phase 441 trials
Phase 4	NCT07608562 Background	Aug 2026 → Jun 2028 expected	cervical incompetence	Wake Forest University Health Sciences	Not yet recruiting	No outcome recorded
Phase 4	NCT07072923 Comparator	Sep 2025 → Jul 2027 expected	osteomyelitis	University of Arizona	Not yet recruiting	No outcome recorded
Phase 4	NCT06814223 Comparator	Oct 2024 → Dec 2027 expected	prosthesis-related infectious disease	Western Galilee Hospital-Nahariya	Recruiting	No outcome recorded
Phase 4	NCT06055712 Comparator	Sep 2023 → Sep 2033 expected	infectious disease	St. Louis University	Enrolling by invitation	No outcome recorded
Phase 4	NCT05977868 Comparator	Aug 2023 → Feb 2025	digestive system infectious disorder	West Virginia University	Terminated	No outcome recorded
Phase 4	NCT05971537 Comparator	Jun 2023 → Oct 2026 expected	infectious peritonitis	Alice Ho Miu Ling Nethersole Hospital	Recruiting	No outcome recorded
Phase 4	NCT05199324 Comparator	Jun 2022 → May 2026 overdue	gram-negative bacterial infections	Tan Tock Seng Hospital	Recruiting	No outcome recorded
Phase 4	NCT05132829 Background	Dec 2021 → Dec 2024	cervical incompetence, pregnancy disorder	Thomas Jefferson University	Unknown	No outcome recorded
Phase 4	NCT04538053 Comparator	Jun 2021 → Dec 2026 expected	infective arthritis, osteomyelitis	Murdoch Childrens Research Institute	Recruiting	No outcome recorded
Phase 4	NCT04707092 Background	Jun 2021 → Jun 2022	ear infection, poisoning	Sunnybrook Health Sciences Centre	Unknown	No outcome recorded
Phase 4	NCT04766996 Background	May → Dec 2021	substance-related disorder	Emory University	Terminated	No outcome recorded
Phase 4	NCT04834310 Background	Apr 2021 → May 2024	breast disorder, poisoning	University of California, Los Angeles	Withdrawn	No outcome recorded
Phase 4	NCT04141787 Comparator	Jul 2019 → Jul 2023	abscess, bacterial arthritis, infectious disorder of the nervous system, osteomyelitis +1	Vancouver Island Health Authority	Unknown	No outcome recorded
Phase 4	NCT04062175 Comparator	Mar → Jun 2019	infectious disease with sepsis	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT03560232 Comparator	Jul 2018 → Feb 2020	—	Mercy Health Ohio	Terminated	No outcome recorded
Phase 4	NCT03190668 Comparator	May 2018 → Jun 2022	idiopathic scoliosis	University of Florida	Completed	No outcome recorded
Phase 4	NCT03432858 Comparator	May 2018 → Dec 2020	carpal tunnel syndrome	WellSpan Health	Completed	No outcome recorded
Phase 4	NCT03402945 Comparator	Mar 2018 → Apr 2023	—	Population Health Research Institute	Completed	No outcome recorded
Phase 4	NCT04303390 Comparator	Feb 2018 → May 2022	—	Saud Al Babtain Cardiac Center	Completed	No outcome recorded
Phase 4	NCT03231228 Comparator	Nov 2017 → Jul 2019	—	B. Braun Medical SA	Terminated	No outcome recorded
Phase 4	NCT01886742 Comparator	Sep 2017 → Oct 2018	obesity disorder	University of Colorado, Denver	Withdrawn	No outcome recorded
Phase 4	NCT03261830 Comparator	Aug 2017 → Mar 2023	—	Sumit Gupta	Completed	No outcome recorded
Phase 4	NCT03094663 Background	Feb 2017 → May 2018	arthropathy	Hospital for Special Surgery, New York	Completed	No outcome recorded
Phase 4	NCT02872038 Comparator	Aug 2015 → Nov 2016	infectious peritonitis	Chulalongkorn University	Completed	No outcome recorded
Phase 4	NCT02433704 Comparator	May 2015 → May 2017	periprosthetic joint infection	Duke University	Withdrawn	No outcome recorded
Phase 4	NCT02534961 Comparator	Jan 2015 → Dec 2017	hepatocellular carcinoma	Taipei Veterans General Hospital, Taiwan	Unknown	No outcome recorded
Phase 4	NCT02307006 Comparator	Jan 2015 → Dec 2016	—	University of Cincinnati	Unknown	No outcome recorded
Phase 4	NCT02324166 Comparator	Jan 2015 → Jan 2016	endophthalmitis	University Health Network, Toronto	Unknown	No outcome recorded
Phase 4	NCT02225821 Comparator	Nov 2014 → Nov 2016	—	Academic Medical Center - University of Amsterdam	Completed	No outcome recorded
Phase 4	NCT02292082 Background	Nov 2014 → Aug 2016	osteoarthritis	Hospital for Special Surgery, New York	Completed	No outcome recorded
Phase 4	NCT02012517 Comparator	Jan 2014 → Dec 2016	—	Sheba Medical Center	Unknown	No outcome recorded
Phase 4	NCT01980082 Comparator	Jan 2014 → Jun 2017	—	Rabin Medical Center	Completed	No outcome recorded
Phase 4	NCT01628666 Background	Dec 2012 → Sep 2017	cardiac rhythm disease	Population Health Research Institute	Completed	No outcome recorded
Phase 4	NCT01721616 Comparator	Nov 2012 → Nov 2014	endometritis	University of Missouri, Kansas City	Withdrawn	No outcome recorded
Phase 4	NCT01619982 Comparator	Feb 2012 → Dec 2014	aortic valve disorder, congenital heart disease	Stanford University	Completed	No outcome recorded
Phase 4	NCT01613092 Background	May 2011 → Nov 2013	cardiac rhythm disease	Population Health Research Institute	Completed	No outcome recorded
Phase 4	NCT01612052 Comparator	May 2011 → Mar 2013	methicillin-resistant staphylococcus aureus infectious disease	CAMC Health System	Unknown	No outcome recorded
Phase 4	NCT01295606 Comparator	Feb → Dec 2011	—	Universitaire Ziekenhuizen KU Leuven	Completed	No outcome recorded
Phase 4	NCT01273818 Comparator	Jan 2011 → Feb 2013	—	Diskapi Teaching and Research Hospital	Completed	No outcome recorded
Phase 4	NCT03877289 Background	Oct 2008 → Jul 2014	cystitis	University of Calgary	Completed	No outcome recorded
Phase 4	NCT00634166 Background	Sep 2007 → Dec 2013	—	Mylan Inc.	Terminated	No outcome recorded

Phase not applicable29 trials
—	NCT07478874 Comparator	Jul → Dec 2025	—	Lahore General Hospital	Completed	No outcome recorded
—	NCT07032883 Background	Jun 2025 → Feb 2026 overdue	female breast carcinoma	Cairo University	Not yet recruiting	No outcome recorded
—	NCT06510452 Comparator	Oct 2024 → Dec 2025 overdue	—	General Committee of Teaching Hospitals and Institutes, Egypt	Not yet recruiting	No outcome recorded
—	NCT06189885 Background	Aug 2024 → Jul 2026 overdue	periprosthetic joint infection	Chang Gung Memorial Hospital	Not yet recruiting	No outcome recorded
—	NCT07337135 Background	Oct 2023 → Apr 2024	morbid obesity	Hospital dos Lusíadas	Completed	No outcome recorded
—	NCT05647993 Background	Dec 2022 → Nov 2023	—	Department of Medical Services Ministry of Public Health of Thailand	Completed	No outcome recorded
—	NCT03593252 Background	Jan 2022 → Jan 2024	Hirschsprung disease, inflammatory bowel disease, meconium ileus, necrotizing enterocolitis	McMaster University	Unknown	No outcome recorded
—	NCT04998513 Comparator	Jan 2022	peritonsillar abscess	Nova Scotia Health Authority	Withdrawn	No outcome recorded
—	NCT04631185 Background	May 2021 → Dec 2023	—	The Plastic Surgery Foundation	Completed	No outcome recorded
—	NCT04288206 Comparator	Jan 2021 → Oct 2023	infectious disease	Legacy Health System	Unknown	No outcome recorded
—	NCT04146883 Background	Aug 2019 → Aug 2020	prosthesis-related infectious disease	National Cheng-Kung University Hospital	Unknown	No outcome recorded
—	NCT02996656 Comparator	Dec 2016 → Dec 2026 expected	bacterial infectious disease	University of Montreal	Recruiting	No outcome recorded
—	NCT02800785 Comparator	May 2016 → Mar 2020	appendicitis	University of Washington	Completed	No outcome recorded
—	NCT02395614 Comparator	Dec 2015 → Dec 2020	breast cancer	Vanderbilt University Medical Center	Completed	No outcome recorded
—	NCT03115177 Comparator	Nov 2015 → Feb 2017	osteoarthritis	Rush University Medical Center	Completed	No outcome recorded
—	NCT02497365 Comparator	Sep 2015 → Jun 2019	keratitis	McGill University Health Centre/Research Institute of the McGill University Health Centre	Completed	No outcome recorded
—	NCT02502877 Background	Jul 2015 → Mar 2016	—	Hospital da Luz, Portugal	Completed	No outcome recorded
—	NCT02809729 Comparator	Jan 2015 → Apr 2017	female breast carcinoma, skin infection	Fabiola Soares Moreira Campos	Completed	No outcome recorded
—	NCT02058979 Comparator	Nov 2014 → Jun 2016	—	University of Virginia	Completed	No outcome recorded
—	NCT02413034 Comparator	Nov 2013 → Dec 2014	periprosthetic joint infection	Parc de Salut Mar	Completed	No outcome recorded
—	NCT01991834 Comparator	Sep 2013 → Mar 2015	infectious disease	Universidade do Vale do Sapucai	Completed	No outcome recorded
—	NCT01823523 Comparator	Jun 2013 → Oct 2015	craniofacial and skeletal defects	Atlantic Center for Oral and Maxillofacial Surgery	Unknown	No outcome recorded
—	NCT01235546 Comparator	May 2011 → Dec 2015	abscess, endometritis, skin infection	Alan Tita	Completed	No outcome recorded
—	NCT02027532 Comparator	Oct 2009 → Jun 2015	infectious disease	University of Tennessee	Terminated	No outcome recorded
—	NCT00818766 Comparator	Mar 2008 → Apr 2011	—	Brigham and Women's Hospital	Completed	No outcome recorded
—	NCT00610987 Comparator	Jan 2008 → Jan 2014	—	University of Missouri-Columbia	Completed	No outcome recorded
—	NCT00787553 Comparator	Jul 2006 → Dec 2008	—	University of Campinas, Brazil	Unknown	No outcome recorded
—	NCT02077400 Comparator	Jan 2006 → Feb 2015	—	HaEmek Medical Center, Israel	Completed	No outcome recorded
—	NCT01248078 Comparator	Mar 2004 → Jan 2010	—	Medical University of Vienna	Completed	No outcome recorded

Evidence & citations 31 cited values

Every value below carries the sentence it was read from. 183 sources stand behind the page.

Field	Value	Cited text
Known as	Cefazolin	“The investigators want to compare whether Methicillin-resistant Staphylococcus Aureaus (MRSA) antibiotic prophylaxis with Cefazolin plus Daptomycin is superior to Cefazolin...” NCT01612052 ↗ 167 “The medical intervention consists of intravenous dexamethasone (10 mg if bodyweight \< 70 kilograms, 20 mg if bodyweight \> 70 kilograms), intravenous cefazolin 2 grams,...” NCT04998513 ↗ “Possible prescribed antibiotics include: trimethoprim and sulfamethoxazole (Septra), Cefalotin, Cephalexin, Cefapirin, Cefdroxil, Cefazolin, Cefradine, Cefacetrile,...” NCT03877289 ↗ “A maximum dose of 2 grams cefazolin in a solution of 1 gram/100 mL sterile saline will be injected into the affected area, followed by a 3-minute application of external...” NCT03732365 ↗ “Calcium sulfate beads will be loaded with best available antibiotics based on surgeon/infectious disease specialist determination from the following options (vancomycin,...” NCT07072923 ↗ “Some commonly used antibiotics for the treatment of PD peritonitis with their suggested concentrations in the antibiotic-lock are quoted as below: Cefazolin 10mg/mL...” NCT05971537 ↗ “'Topical Antimicrobial/Antifungal Medications' Various topical antimicrobials and antifungals include: Bacitracin; Amphotericin B; Silver Sulfadiazine; Cefazolin; Vancomycin;...” NCT00634166 ↗ “Vancomycin IV, linezolid IV or oral (outside European Union only), clindamycin IV or oral, flucloxacillin IV or oral, cefazolin IV, or cephalexin oral provided locally by the...” NCT03176134 ↗ “The investigators will administer to every patient: cefazolin 2g iv bolus, ketorolac 30 mg iv bolus, pantoprazole 40 mg iv bolus, paracetamol 1g iv perfusion (initiated 30...” NCT02502877 ↗ “Patients will be randomized at the time of surgery to receive intravenous cefazolin or clindamycin (weight-based dosing) as a pre-operative antibiotic within 60 minutes of...” NCT05367479 ↗ “Antibiotic comparator drug, IV and/or orally for 10 days. Antibiotic comparator included the following: Vancomycin, Linezolid, Clindamycin, Flucloxacillin, Cefazolin, Cephalexin.” NCT02276482 ↗ “tumescent formulation of cefazolin (1gm) and metronidazole (500mg/100ml) in a dilute solution of lidocaine (1gm), epinephrine (1mg) in 100ml and sodium bicarbonate (10mEq/10ml)” NCT03226626 ↗ “This group was only treated with pre-procedural (pacemaker or ICD implantation) prophylactic once intravenous antibiotics (cefazolin 1000mg or else if allergy to cefazolin).” NCT04146883 ↗ “Commonly used intravenous antibiotics (and doses) for treatment of Gram-negative bacteraemia include ceftriaxone 2 g daily or cefazolin 2 g three times daily.” NCT05199324 ↗ “a single preoperative intravenous dose of 1000 mg of cefazolin (cefazolin group, n = 228) or sodium chloride (0.9%; saline group, n = 242).” PMID 29279933 ↗ Dec 2017 “Parenteral prophylactic antibiotics (cefazolin), 1st dose at the time of induction of anesthesia, 2nd dose after 12hs from the surgery.” NCT06607887 ↗ “IV doses of metronidazole (12.5mg/kg up to 500mg) and cefazolin (25mg/kg up to 1g). One dose for study arm, two for comparative arm.” NCT01420367 ↗ “Antibiotic in case of now allergies will be Cefazolin at induction and Amoxicillin plus Clavulanic acid for the oral treatment week” NCT04707092 ↗ “Intravenous anti-staphylococcal beta-lactam, either cefazolin or nafcillin, per the discretion of the treating physician.” NCT07376889 ↗ “Azithromycin 500 milligrams intravenously once and cefazolin 2 grams intravenously every 8 hours for up to three doses” NCT06488781 ↗ “Both two group will receive standard prophylaxis antibiotic CEFAZOLIN (zinol) (at a dose of 1 g) 2 hours preoperative” NCT03502356 ↗ “One group will receive Cefazolin 1gm intravenous + Azithromycin 500mg intravenous 30-60 minutes prior to incision.” NCT00805545 ↗ “with either first generation cephalosporin (cefazolin) (if absence of colonization to Pseudomonas aeruginosa)” NCT04292054 ↗ “Patients will be treated with antibiotics (Cefazolin, Tobramycin or Moxifloxacin) we per treating physician” NCT07308938 ↗ “Intravenous cefazolin, a cephalosporin antibiotic, will be prescribed to all patients before surgery.” NCT04631185 ↗ “Cefazolin is therefore the preferred treatment for invasive MSSA infections in the target population.” NCT06093269 ↗ “Single dose of Cefazolin and Vancomycin preoperatively, bacitracin wash and cefalexin post operative.” NCT01628666 ↗ “single antibiotic chemotherapy(Cefazolin) 2 gm iv within 30 minutes before skin incision” NCT04062175 ↗ “Patients undergoing major surgery received cefazolin 2 g before surgical incision.” PMID 28505360 ↗ Jun 2017 “Intravenous ciprofloxacin 400mg every 12 hours and cefazolin 1000mg every 6 hours” NCT05162625 ↗ “triple antibiotic solution will contain 1 g of cefazolin, 50,000 U of bacitracin” NCT02395614 ↗ “Intravenous 2 gram cefazolin every 8 hours for 24 hours beginning at surgery” NCT02012517 ↗ “a single dose of cefazolin administered within 1 hour before skin incision” NCT07043855 ↗ “Participant given IV cefazolin plus ertapenem dosing per standard of care.” NCT07148960 ↗ “The standard dose of Cefazolin will be administered intravenously.” NCT01886742 ↗ “Continuous Infusion Flucloxacillin and Cefazolin Coupled With TDM” NCT05655091 ↗ “2g of i.v. cefazolin singleshot administered before skin incision” NCT01248078 ↗ “Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗ “* Cefazolin for antibiotic prophylaxis,” NCT07337135 ↗ “Ancef 1 g intravenous (IV) ( cefazolin)” NCT07032883 ↗ “Cefazolin” NCT06488781 ↗ NCT02717871 ↗ NCT03248063 ↗ NCT03862170 ↗ NCT03283878 ↗ NCT06055712 ↗ NCT02368015 ↗ NCT05205486 ↗ NCT02324166 ↗ NCT03466645 ↗ NCT03432858 ↗ NCT02344511 ↗ NCT01238276 ↗ NCT04731025 ↗ NCT02800785 ↗ NCT03261830 ↗ NCT00787553 ↗ NCT06336824 ↗ NCT02365493 ↗ NCT03801252 ↗ NCT04141787 ↗ NCT06567808 ↗ NCT07658378 ↗ NCT03231228 ↗ NCT01613092 ↗ NCT06355115 ↗ NCT00550290 ↗ NCT02593201 ↗ NCT01121354 ↗ NCT02872038 ↗ NCT01867138 ↗ NCT01002911 ↗ NCT02838940 ↗ NCT00867295 ↗ NCT03094663 ↗ NCT05447559 ↗ NCT02413034 ↗ NCT03046511 ↗ NCT00330278 ↗ NCT06406114 ↗ NCT00467948 ↗ NCT02208063 ↗ NCT01401179 ↗ NCT04763486 ↗ NCT03672149 ↗ NCT01114516 ↗ NCT03402945 ↗ NCT07549542 ↗ NCT02497365 ↗ NCT07111702 ↗ NCT04538053 ↗ NCT06030713 ↗ NCT04288206 ↗ NCT02027532 ↗ NCT04303390 ↗ NCT06640491 ↗ NCT01756924 ↗ NCT01755026 ↗ NCT04875728 ↗ NCT02216227 ↗ NCT03578965 ↗ NCT05137119 ↗ NCT01904500 ↗ NCT03213249 ↗ NCT01479283 ↗ NCT01029782 ↗ NCT00438269 ↗ NCT00108433 ↗ NCT05304871 ↗ NCT02996656 ↗ NCT01904357 ↗ NCT03595852 ↗ NCT06510452 ↗ NCT04516148 ↗ NCT02307006 ↗ NCT06576154 ↗ NCT06710977 ↗ NCT01503606 ↗ NCT01991834 ↗ NCT06189885 ↗ NCT00811603 ↗ NCT03593252 ↗ NCT02285140 ↗ NCT01823523 ↗ NCT03742908 ↗ NCT01785641 ↗ NCT01845363 ↗ NCT02809729 ↗ NCT02446782 ↗ NCT03853096 ↗ NCT03190668 ↗ NCT01880112 ↗ NCT02049944 ↗ NCT01273818 ↗ NCT00610987 ↗ NCT06327113 ↗ NCT05132829 ↗ NCT07478874 ↗ NCT01810354 ↗ NCT05852158 ↗ NCT01980082 ↗ NCT03675854 ↗ NCT01721616 ↗ NCT00323219 ↗ NCT02433704 ↗ NCT02503904 ↗ NCT03478163 ↗ NCT04834310 ↗ NCT01400867 ↗ NCT01619982 ↗ NCT06402591 ↗ NCT03115177 ↗ NCT05309304 ↗ NCT04775953 ↗ NCT00850122 ↗ NCT05977868 ↗ NCT04818931 ↗ NCT00818766 ↗ NCT02534961 ↗ NCT05647993 ↗ NCT02493894 ↗ NCT07655596 ↗ NCT06920147 ↗ NCT01295606 ↗ NCT03560232 ↗ NCT02292082 ↗ NCT01792804 ↗ NCT07608562 ↗
Known as	46083	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Acef	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Ancef	“Ancef, a 1st generation cephalosporin, was used as the primary antibiotic” NCT02579161 ↗ 5 “Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗ “Ancef 1 g intravenous (IV) ( cefazolin)” NCT07032883 ↗ “Ancef or Vancomycin” NCT01458223 ↗ NCT01127880 ↗ NCT04766996 ↗
Known as	Cefacidal	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefacidil	“Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗
Known as	Cefamedin	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefamezin	“Cefazolin (Cefamezin)” NCT04763486 ↗ 2 NCT02404064 ↗ NCT01899781 ↗
Known as	Cefamezine	ClinicalTrials.gov intervention name — accepted as the source's own label NCT06814223 ↗
Known as	Cefazil	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefazolin (Ancef)	“Cefazolin (Ancef)” NCT00818766 ↗
Known as	Cefazolin and dextrose	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefazolin injection	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	cefazolin sodium	“Patients received preoperative antibacterial prophylaxis with cefazolin sodium (or other drug if the patient was allergic to cefazolin).” PMID 23325435 ↗ May 2013 2 “Drug: CEZ, cefazolin sodium” NCT01805856 ↗ NCT00636831 ↗
Known as	Cefazolin sodium salt	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefazolin: Brand Names Ancef	“Cefazolin: Brand Names Ancef” NCT01619982 ↗
Known as	Cefazolina	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Cefazoline	“Intravenous (IV) cefazoline 1g” NCT03518463 ↗ 1 NCT01537380 ↗
Known as	cephazolin	“standard of care (cephazolin or clindamycin)” NCT01235546 ↗ 2 NCT04079686 ↗ NCT02077400 ↗
Known as	CEZ	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01805856 ↗
Known as	CZO	“flucloxacillin (FLU) or cefazolin (CZO)” NCT05655091 ↗
Known as	Gramaxin	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	J01DB04	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Kefzol	“Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗
Known as	NSC-291561	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	SK&F 41558	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Totacef	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Known as	Zolicef	ChEMBL registry synonym — accepted as the source's own label CHEMBL1435 ↗
Action	Inhibit	“inhibition of bacterial cell wall synthesis” NCT04775953 ↗
Modality	Small molecule	“Cefazolin is a first-generation cephalosporin commonly used for perioperative surgical prophylaxis” NCT01886742 ↗
Route	Intravenous	“Cefazolin IV” NCT00108433 ↗