Drugs / Cefazolin
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Cefazolin

Small molecule

Developed for
skin infection · infectious disease · obesity disorder · staphylococcus aureus infection · pregnancy disorder · appendicitis · cellulitis · chronic ulcer of skin
+36 more · endometritis · peritonitis · puerperal infection · bacterial infectious disease · breast disorder · cervical incompetence · disease of the tendon · empyema · gram-positive bacterial infections · infectious disease with sepsis · infectious peritonitis · larynx cancer · methicillin-resistant staphylococcus aureus infectious disease · methicillin-susceptible staphylococcus aureus infectious disease · neonatal sepsis · nosocomial infection · parathyroid gland disorder · periprosthetic joint infection · pneumonia · prostate cancer · prosthesis-related infectious disease · thyroid gland disorder · ulcer of lower limbs · abscess · acute endophthalmitis · bacterial arthritis · craniofacial and skeletal defects · hemopneumothorax · infectious disorder of the nervous system · infective arthritis · keratitis · osteomyelitis · preterm premature rupture of the membranes · primary bacterial infectious disease · skin disease caused by bacterial infection · staphylococcal infection
Investigated by
Radboud University Medical Center · B. Braun Medical SA · Chinese University of Hong Kong · Duke University · HaEmek Medical Center, Israel · Hamilton Health Sciences Corporation
+104 more · Helwan University · Menzies School of Health Research · Monash University · Sonescence, Inc. · Tan Tock Seng Hospital · The Methodist Hospital Research Institute · The Physicians' Services Incorporated Foundation · The University of Queensland · University of British Columbia · University of California, Irvine · University of Florida · University of Oklahoma · West Virginia University · ANZCA CTN · Aalborg University Hospital · Aarhus University Hospital · Abdul El-Rabbany · Al-Gumhori Teaching Hospital · Aleppo University Hospital Resident Team · American Association of Hip and Knee Surgeons · Aotearoa Clinical Trials · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Aultman Health Foundation · Australasian Kidney Trials Network · Australasian Society for Infectious Diseases · Baxter Healthcare Corporation · Berry Consultants · CHU de Quebec-Universite Laval · CR-CSSS Champlain-Charles-Le Moyne · Canadian Critical Care Trials Group · Canadian Institutes of Health Research (CIHR) · Carmel Medical Center · Case Western Reserve University · Cedars-Sinai Medical Center · Chulalongkorn University · Dartmouth-Hitchcock Medical Center · Drexel University · Esbjerg Hospital - University Hospital of Southern Denmark · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Federal University of Pernambuco · German Research Foundation · Heinrich-Heine University, Duesseldorf · Herlev and Gentofte Hospital · Hospital Italiano de Buenos Aires · Intermountain Health Care, Inc. · Ito Hospital · King's College London · Massachusetts General Hospital · McGill University Health Centre/Research Institute of the McGill University Health Centre · Medical College of Wisconsin · Medical University of South Carolina · Medstar Health Research Institute · Meir Medical Center · MemorialCare · MemorialCare Health System · Michael Stitely · Mikkel Herly · Minia University Hospital · Monash Medical Centre · National Institute of Allergy and Infectious Diseases (NIAID) · Northwestern University · Odense University Hospital · Orthopedic Research and Education Foundation · Parexel · Pfizer · Phillip Brian Smith · Post Graduate Institute of Medical Education and Research, Chandigarh · Queensland University of Technology · Rambam Health Care Campus · Rutgers, The State University of New Jersey · Saiful Anwar Hospital · Sana'a University · Singapore Infectious Diseases Clinical Research Network · all 110 on the full record

Regulatory milestones approvals, filings & regulatory actions · 10 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) CEFAZOLIN SODIUM — 2024-12-18 – 2026-02-13 fda.gov ↗
Label expansions (4) US (FDA) CEFAZOLIN AND DEXTROSE — 2012-01-13 – 2024-08-26 fda.gov ↗
Label expansions (3) US (FDA) CEFAZOLIN IN DEXTROSE — 2021-02-01 – 2024-05-31 fda.gov ↗
Approved US (FDA) ANCEF — 1973-10-04 fda.gov ↗

Trials 77 · started per year

today
US approved 1973
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06710977 Jan 2022 → Sep 2024 cataract Tan Tock Seng Hospital Completed No outcome recorded
Phase 0 NCT03853096 Apr 2019 → Apr 2020 — University of British Columbia Unknown No outcome recorded
Phase 0 NCT03801252 Dec 2018 → Jun 2021 obesity disorder University of Oklahoma Completed No outcome recorded
Phase 17 trials
Phase 1 NCT05205486 Apr 2022 → Jul 2023 infectious disease B. Braun Medical SA Completed No outcome recorded
Phase 1 NCT05309304 Feb → Aug 2022 — Baxter Healthcare Corporation Completed No outcome recorded
Phase 1 NCT03672149 Jul 2019 → Dec 2022 — Drexel University Unknown No outcome recorded
Phase 1 NCT05367479 Jul 2018 → Jan 2020 hypertensive disorder, morbid obesity Medical College of Wisconsin Completed No outcome recorded
Phase 1 NCT01904500 Aug 2013 → Apr 2014 obesity disorder, pregnancy disorder University of Pittsburgh Completed No outcome recorded
Phase 1 NCT00850122 Jul 2013 → Jul 2018 infectious disease with sepsis Phillip Brian Smith Completed No outcome recorded
Phase 1 NCT01121354 Dec 2009 → Feb 2010 infectious disease B. Braun Medical SA Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT06640491 May 2025 → Dec 2030 expected — The Methodist Hospital Research Institute Recruiting No outcome recorded
Phase 27 trials
Phase 2 NCT06406114 May 2025 → Jul 2028 expected anaphylaxis, drug allergy, drug pseudoallergy Massachusetts General Hospital Recruiting No outcome recorded
Phase 2 NCT06488781 Apr 2025 → Dec 2028 expected pregnancy disorder University of Oklahoma Recruiting No outcome recorded
Phase 2 NCT06327113 May 2024 → May 2027 expected chronic ulcer of skin University of California, Los Angeles Recruiting No outcome recorded
Phase 2 NCT06355115 Sep 2023 → Sep 2024 — University of Brawijaya Unknown No outcome recorded
Phase 2 NCT03732365 Feb 2019 → Jan 2020 chronic ulcer of skin Sonescence, Inc. Unknown No outcome recorded
Phase 2 NCT03578965 Jul 2018 → Nov 2021 low grade vulvar intraepithelial neoplasia, vulvar benign neoplasm Washington University School of Medicine Completed No outcome recorded
Phase 2 NCT00438269 Feb 2003 → Mar 2005 nosocomial infection, pneumonia Canadian Critical Care Trials Group Completed No outcome recorded
Phase 313 trials · 1 met primary · 1 missed
Phase 3 NCT06576154 Aug 2024 → Aug 2025 overdue skin infection University of Aleppo Recruiting No outcome recorded
Phase 3 NCT04731025 Jan 2021 → Sep 2026 overdue breast disorder, poisoning, prosthesis-related infectious disease Mikkel Herly Active not recruiting No outcome recorded
Phase 3 NCT06402591 Jan 2019 → Dec 2023 periprosthetic joint infection Radboud University Medical Center Unknown No outcome recorded
Phase 3 NCT03046511 Mar 2017 → Dec 2023 infectious peritonitis Carmel Medical Center Unknown No outcome recorded
Phase 3 NCT02838940 Aug 2016 → Aug 2019 — Tel-Aviv Sourasky Medical Center Unknown No outcome recorded
Phase 3 NCT02365493 Aug 2015 → Oct 2018 methicillin-resistant staphylococcus aureus infectious disease Menzies School of Health Research Terminated Missed primary
Phase 3 NCT03862170 Feb 2015 → Feb 2020 prostate cancer CR-CSSS Champlain-Charles-Le Moyne Terminated No outcome recorded
Phase 3 NCT01792804 Dec 2013 → Mar 2020 staphylococcus aureus infection Heinrich-Heine University, Duesseldorf Completed Met primary
Phase 3 NCT00811603 Aug 2008 → Jun 2009 infectious disease MemorialCare Completed No outcome recorded
Phase 3 NCT01867138 Mar 2007 → Aug 2010 neonatal sepsis Hospital Italiano de Buenos Aires Completed No outcome recorded
Phase 425 trials
Phase 4 NCT07655596 Jul → Sep 2026 overdue — Helwan University Not yet recruiting No outcome recorded
Phase 4 NCT07658378 Jul → Sep 2026 overdue — Helwan University Not yet recruiting No outcome recorded
Phase 4 NCT06567808 Mar 2026 → Apr 2028 expected skin infection Hamilton Health Sciences Corporation Not yet recruiting No outcome recorded
Phase 4 NCT07376889 Feb 2026 → Jan 2029 expected staphylococcus aureus infection Intermountain Health Care, Inc. Recruiting No outcome recorded
Phase 4 NCT07549542 Oct 2025 → Oct 2026 expected — Rutgers, The State University of New Jersey Enrolling by invitation No outcome recorded
Phase 4 NCT07148960 Sep 2025 → Jul 2027 expected staphylococcus aureus infection West Virginia University Enrolling by invitation No outcome recorded
Phase 4 NCT06920147 May 2025 → Mar 2027 expected — The University of Texas Health Science Center, Houston Not yet recruiting No outcome recorded
Phase 4 NCT06607887 Aug → Nov 2024 overdue skin infection Minia University Hospital Recruiting No outcome recorded
Phase 4 NCT05852158 Jan 2024 → Jan 2027 expected — Abdul El-Rabbany Recruiting No outcome recorded
Phase 4 NCT06093269 Nov 2023 → Dec 2025 overdue bacterial infectious disease University Hospital, Tours Active not recruiting No outcome recorded
Phase not applicable20 trials · 2 met primary · 3 missed
— NCT07043855 May 2026 → Oct 2028 expected infectious disease Asan Medical Center Enrolling by invitation No outcome recorded
— NCT05304871 Jan 2024 → Mar 2027 — Dartmouth-Hitchcock Medical Center Withdrawn No outcome recorded Stop: Business
— NCT07111702 Oct 2023 → May 2024 — Sana'a University Completed No outcome recorded
— NCT04763486 Mar 2021 → Mar 2022 puerperal infection Meir Medical Center Unknown No outcome recorded
— NCT06030713 Mar 2019 → Oct 2022 poisoning University Medical Center Groningen Completed No outcome recorded
— NCT03248063 Sep 2018 → Feb 2024 methicillin-susceptible staphylococcus aureus infectious disease Assistance Publique - Hôpitaux de Paris Completed Met primary
— NCT03742908 Jun 2018 → Oct 2021 breast neoplasm Tianjin Medical University Cancer Institute and Hospital Unknown No outcome recorded
— NCT04818931 Apr 2018 → Jun 2019 breast cancer CHU de Quebec-Universite Laval Completed Missed primary
— NCT03595852 Mar → Sep 2018 — University of Rwanda Completed No outcome recorded
— NCT02285140 Apr 2015 → Mar 2025 — Hamilton Health Sciences Corporation Terminated No outcome recorded Stop: Business
Phase not stated1 trial
— NCT01238276 — cellulitis, ulcer of lower limbs Sonescence, Inc. No longer available No outcome recorded
Comparator or background therapy99 trials
Phase 0 NCT05849090 Comparator Mar 2023 → Dec 2024 infectious disease University of Utah Completed No outcome recorded
Phase 1 NCT04875728 Comparator Sep 2020 → Feb 2027 expected cutaneous melanoma M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 1 NCT03213249 Comparator Jul 2017 → Sep 2018 breast disorder Washington University School of Medicine Completed No outcome recorded
Phase 1 NCT01904357 Comparator Mar → Aug 2013 infectious disease B. Braun Medical SA Completed No outcome recorded
Phase 1/2 NCT03502356 Comparator Apr → Jun 2018 — Ain Shams University Unknown No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 177 sources stand behind the page.

FieldValueCited text
Known as Cefazolin “The investigators want to compare whether Methicillin-resistant Staphylococcus Aureaus (MRSA) antibiotic prophylaxis with Cefazolin plus Daptomycin is superior to Cefazolin...” NCT01612052 ↗
168

“The medical intervention consists of intravenous dexamethasone (10 mg if bodyweight \< 70 kilograms, 20 mg if bodyweight \> 70 kilograms), intravenous cefazolin 2 grams,...” NCT04998513 ↗

“Possible prescribed antibiotics include: trimethoprim and sulfamethoxazole (Septra), Cefalotin, Cephalexin, Cefapirin, Cefdroxil, Cefazolin, Cefradine, Cefacetrile,...” NCT03877289 ↗

“A maximum dose of 2 grams cefazolin in a solution of 1 gram/100 mL sterile saline will be injected into the affected area, followed by a 3-minute application of external...” NCT03732365 ↗

“Calcium sulfate beads will be loaded with best available antibiotics based on surgeon/infectious disease specialist determination from the following options (vancomycin,...” NCT07072923 ↗

“Some commonly used antibiotics for the treatment of PD peritonitis with their suggested concentrations in the antibiotic-lock are quoted as below: Cefazolin 10mg/mL...” NCT05971537 ↗

“'Topical Antimicrobial/Antifungal Medications' Various topical antimicrobials and antifungals include: Bacitracin; Amphotericin B; Silver Sulfadiazine; Cefazolin; Vancomycin;...” NCT00634166 ↗

“Vancomycin IV, linezolid IV or oral (outside European Union only), clindamycin IV or oral, flucloxacillin IV or oral, cefazolin IV, or cephalexin oral provided locally by the...” NCT03176134 ↗

“The investigators will administer to every patient: cefazolin 2g iv bolus, ketorolac 30 mg iv bolus, pantoprazole 40 mg iv bolus, paracetamol 1g iv perfusion (initiated 30...” NCT02502877 ↗

“Patients will be randomized at the time of surgery to receive intravenous cefazolin or clindamycin (weight-based dosing) as a pre-operative antibiotic within 60 minutes of...” NCT05367479 ↗

“Antibiotic comparator drug, IV and/or orally for 10 days. Antibiotic comparator included the following: Vancomycin, Linezolid, Clindamycin, Flucloxacillin, Cefazolin, Cephalexin.” NCT02276482 ↗

Show 158 more sources

Known as Ancef “Ancef, a 1st generation cephalosporin, was used as the primary antibiotic” NCT02579161 ↗
5

“Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗

“Ancef 1 g intravenous (IV) ( cefazolin)” NCT07032883 ↗

“Ancef or Vancomycin” NCT01458223 ↗

NCT01127880 ↗

NCT04766996 ↗

Known as Cefacidil “Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗
Known as Cefamezin “Cefazolin (Cefamezin)” NCT04763486 ↗
2

NCT01899781 ↗

NCT02404064 ↗

Known as Cefazolin (Ancef) “Cefazolin (Ancef)” NCT00818766 ↗
Known as cefazolin sodium “Patients received preoperative antibacterial prophylaxis with cefazolin sodium (or other drug if the patient was allergic to cefazolin).” PMID 23325435 ↗ May 2013
2

“Drug: CEZ, cefazolin sodium” NCT01805856 ↗

NCT00636831 ↗

Known as Cefazolin: Brand Names Ancef “Cefazolin: Brand Names Ancef” NCT01619982 ↗
Known as CEZ ClinicalTrials.gov intervention name — accepted as the source's own label NCT01805856 ↗
Known as CZO “flucloxacillin (FLU) or cefazolin (CZO)” NCT05655091 ↗
Known as Kefzol “Cephalosporin - Cefazolin, (Ancef, Kefzol, Cefacidil)” NCT05849090 ↗
Action Inhibit “inhibition of bacterial cell wall synthesis” NCT04775953 ↗
Modality Small molecule “Cefazolin is a first-generation cephalosporin commonly used for perioperative surgical prophylaxis” NCT01886742 ↗
Route Intravenous “Cefazolin IV” NCT00108433 ↗