Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)

Phase 4 Completed 86 enrolled Hospital for Special Surgery, New York

RandomizedParallel-groupDouble-blindTreatment

Summary

A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK) versus the Periarticular Injection (PAI) - in patients undergoing total knee arthroplasty. Primary outcome is NRS pain scores with ambulation on postoperative day one (24 hours post-block administration).

Timeline

Start: 2017-02-28
Primary completion: 2018-05-31
Completion: 2018-09-01

Publications

Kim DH, Beathe JC, Lin Y, YaDeau JT, Maalouf DB, Goytizolo E, Garnett C, Ranawat AS, Su EP, Mayman DJ, Memtsoudis SG. Addition of Infiltration Between the Popliteal Artery and the Capsule of the Posterior Knee and Adductor Canal Block to Periarticular Injection Enhances Postoperative Pain Control in Total Knee Arthroplasty: A Randomized Controlled Trial. Anesth Analg. 2019 Aug;129(2):526-535. doi: 10.1213/ANE.0000000000003794.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	15 ml	Other
Subject	Bupivacaine	Other / unclassified	20 ml	Other
Subject	Bupivacaine	Other / unclassified	25 ml	Other
Subject	Bupivacaine	Other / unclassified	30 ml	Other
Comparator	Dexamethasone	Small molecule	2 mg	Intravenous
Background	Cefazolin	Small molecule	500 mg	Other
Background	Epinephrine	Other / unclassified	—	Other
Background	Methylprednisolone	Other / unclassified	40 mg	Other

Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)

Summary

Timeline

Publications

Drugs

Indications