drugset / Trial / NCT02502877
Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia
RandomizedParallel-groupSingle-blindSupportive care
Summary
The present study is a pilot study aiming to compare the variation in core temperature (measured through the non-invasive device Spot-OnTM3MTM) in patients submitted to neuraxial anesthesia for orthopedic procedures, during sedation with midazolam vs propofol.
Timeline
- Start
- 2015-07
- Primary completion
- 2016-03
- Completion
- 2016-03
Publications
- Background Sun Z, Honar H, Sessler DI, Dalton JE, Yang D, Panjasawatwong K, Deroee AF, Salmasi V, Saager L, Kurz A. Intraoperative core temperature patterns, transfusion requirement, and hospital duration in patients warmed with forced air. Anesthesiology. 2015 Feb;122(2):276-85. doi: 10.1097/ALN.0000000000000551.
- Background Eshraghi Y, Nasr V, Parra-Sanchez I, Van Duren A, Botham M, Santoscoy T, Sessler DI. An evaluation of a zero-heat-flux cutaneous thermometer in cardiac surgical patients. Anesth Analg. 2014 Sep;119(3):543-549. doi: 10.1213/ANE.0000000000000319.
- Background Jeong CW, Ju J, Lee DW, Lee SH, Yoon MH. Lipid-emulsion propofol less attenuates the regulation of body temperature than micro-emulsion propofol or sevoflurane in the elderly. Yonsei Med J. 2012 Jan;53(1):198-203. doi: 10.3349/ymj.2012.53.1.198.
- Background Iden T, Horn EP, Bein B, Bohm R, Beese J, Hocker J. Intraoperative temperature monitoring with zero heat flux technology (3M SpotOn sensor) in comparison with sublingual and nasopharyngeal temperature: An observational study. Eur J Anaesthesiol. 2015 Jun;32(6):387-91. doi: 10.1097/EJA.0000000000000232.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 0.033 mg | — |
| Subject | Midazolam | Small molecule | 0.05 mg | — |
| Comparator | Propofol | Small molecule | 1 ug/ml | — |
| Background | Acetaminophen | Small molecule | 1 g | Intravenous |
| Background | Cefazolin | Small molecule | 2 g | Intravenous |
| Background | Ketorolac | Other / unclassified | 30 mg | Intravenous |
| Background | Pantoprazole | Other / unclassified | 40 mg | Intravenous |
Indications
No indication recorded.