Cefazolin Pharmacokinetics: Elimination Clearance in Neonates

Phase 4 Completed 40 enrolled Universitaire Ziekenhuizen KU Leuven

NaSingle-groupOpen-labelPrevention

Summary

To document cefazolin disposition (concentration/time profile, protein binding, metabolism, renal elimination characteristics) and its covariates in neonates following intravenous administration of the drug at induction of anesthesia, prior to an invasive procedure To evaluate if optimalisation of cefazolin dose regimen during neonatal life is needed

Timeline

Start: 2011-02
Primary completion: 2011-12
Completion: 2011-12

Publications

Elkayal O, Allegaert K, Spriet I, Smits A, Seghaye MC, Charlier C, Dreesen E. Population pharmacokinetics of cefazolin in maternal and umbilical cord plasma, and simulated exposure in term neonates. J Antimicrob Chemother. 2021 Nov 12;76(12):3229-3236. doi: 10.1093/jac/dkab329.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cefazolin	Small molecule	50 mg/kg	Intravenous

Indications

No indication recorded.