drugset / Trial / NCT01756924
Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection
RandomizedParallel-groupOpen-labelTreatment
Summary
To determine if oral antibiotic treatment with CEM-102 and Rifampin is as effective and safe as the standard of care antibiotic therapy for the treatment of hip and knee prosthetic joint or spacer infections
Timeline
- Start
- 2012-12
- Primary completion
- 2014-07
- Completion
- 2014-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fusidic Acid | Unknown | — | Oral |
| Subject | Rifampin | Small molecule | — | Oral |
| Comparator | Cefazolin | Small molecule | — | Intravenous |
| Comparator | Ceftaroline | Other / unclassified | — | Intravenous |
| Comparator | Ceftriaxone | Other / unclassified | — | Intravenous |
| Comparator | Ciprofloxacin | Small molecule | — | Intravenous |
| Comparator | Daptomycin | Other / unclassified | — | Intravenous |
| Comparator | Levofloxacin | Small molecule | — | Intravenous |
| Comparator | Linezolid | Other / unclassified | — | Intravenous |
| Subject | Rifampin | Small molecule | — | Intravenous |
| Comparator | Vancomycin | Other / unclassified | — | Intravenous |
| Comparator | nafcillin | Small molecule | — | Intravenous |
| Comparator | oxacillin | Small molecule | — | Intravenous |
| Comparator | trimethoprim-sulfamethoxazole | Unknown | — | Intravenous |