Cotrimoxazole
Trials 20
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials | ||||||
| Phase 2 | NCT04985110 | Jul 2021 → Jul 2023 | bacteriuria, infectious disease with sepsis, prostate cancer, urinary tract infection | Indonesia University | Unknown | No outcome recorded |
| Phase 2 | NCT04470531 | Jul → Oct 2020 | COVID-19 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Unknown | No outcome recorded |
| Phase 2 | NCT01832987 | Oct 2013 → Aug 2014 | tuberculosis | University Medical Center Groningen | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT04884490 | May → Oct 2021 | pneumonia | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Completed | No outcome recorded |
| Phase 2/3 | NCT04310930 | Mar 2020 → Jun 2029 expected | pulmonary non-tuberculous mycobacterial infection | The University of Queensland | Recruiting | No outcome recorded |
| Phase 310 trials · 1 met primary · 2 missed | ||||||
| Phase 3 | NCT05696093 | Oct 2023 → Oct 2026 expected | — | Assistance Publique - Hôpitaux de Paris | Recruiting | No outcome recorded |
| Phase 3 | NCT04395365 | Jun 2019 → Oct 2025 | infectious peritonitis | University College, London | Unknown | No outcome recorded |
| Phase 3 | NCT01746199 | Dec 2013 → Oct 2015 | HIV infectious disease, malaria | Institut Pasteur | Completed | No outcome recorded |
| Phase 3 | NCT01777737 | Nov 2013 → Nov 2015 | idiopathic pulmonary fibrosis | Andalusian Public Foundation for Health Research in Seville | Terminated | No outcome recorded |
| Phase 3 | NCT01053325 | Sep 2010 → Dec 2012 | HIV infectious disease, malaria | Institute of Tropical Medicine, Belgium | Completed | No outcome recorded |
| Phase 3 | NCT00711906 | Feb 2009 → Feb 2010 | malaria | Institute of Tropical Medicine, Belgium | Terminated | No outcome recorded |
| Phase 3 | NCT00427076 | Jun 2007 → May 2014 | infectious disease with sepsis, meningitis, pneumonia, staphylococcal infection | Rabin Medical Center | Completed | Missed primary |
| Phase 3 | NCT00396526 | Apr 2004 → Apr 2006 | pneumonia | King George's Medical University | Completed | Missed primary |
| Phase 3 | NCT00189384 | Nov 2003 → Dec 2005 | bacterial infectious disease with sepsis | Aga Khan University | Unknown | No outcome recorded |
| Phase 3 | NCT00330304 | Jan 2003 → Nov 2011 | tuberculosis | University of Cape Town | Completed | Met primary |
| Phase 43 trials | ||||||
| Phase 4 | NCT05544565 | Mar 2023 → Jan 2028 expected | acute pyelonephritis | Assistance Publique - Hôpitaux de Paris | Recruiting | No outcome recorded |
| Phase 4 | NCT00137657 | Feb 2002 → Nov 2003 | HIV infectious disease, diarrheal disease, malaria, pneumonia | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| Phase 4 | NCT00156546 | May 2000 → Jul 2006 | urinary tract infection | University of Padova | Unknown | No outcome recorded |
| Phase not applicable2 trials · 1 missed | ||||||
| — | NCT00355602 | Jul 2006 → Dec 2008 | ulcerative colitis | University of Dundee | Completed | No outcome recorded |
| — | NCT00198627 | Dec 2003 → Sep 2007 | bacterial infectious disease | Johns Hopkins Bloomberg School of Public Health | Completed | Missed primary |
| Comparator or background therapy13 trials | ||||||
| Phase 2 | NCT01756924 Comparator | Dec 2012 → Jul 2014 | periprosthetic joint infection | Arrevus Inc. | Terminated | No outcome recorded |
| Phase 2 | NCT01701297 Comparator | Feb 2012 → Oct 2014 | cirrhosis of liver | Nottingham University Hospitals NHS Trust | Terminated | No outcome recorded |
| Phase 2 | NCT01229761 Comparator | May 2011 → Mar 2015 | HIV infectious disease, anemia, neutropenia | Harvard School of Public Health (HSPH) | Completed | No outcome recorded |
| Phase 3 | NCT02773407 Comparator | May 2016 → Aug 2019 | unexplained long-lasting fever/inflammatory syndrome | Oxford University Clinical Research Unit, Vietnam | Completed | No outcome recorded |
| Phase 3 | NCT00934492 Comparator | Nov 2009 → Apr 2014 | infectious disease, nutritional disorder | University of Oxford | Completed | No outcome recorded |
| Phase 4 | NCT05575427 Background | Nov 2022 → Jul 2024 | nosocomial infection | Mahidol University | Unknown | No outcome recorded |
| Phase 4 | NCT03633643 Comparator | Oct 2018 → Oct 2022 | prostatocystitis | University Hospital, Basel, Switzerland | Completed | No outcome recorded |
| Phase 4 | NCT03187834 Comparator | Jul → Sep 2017 | — | University of California, San Francisco | Completed | No outcome recorded |
| Phase 4 | NCT03087890 Comparator | Mar 2017 → Jul 2019 | HIV infectious disease, pneumocystosis | University of Bergen | Completed | No outcome recorded |
| Phase 4 | NCT01420341 Comparator | Aug 2011 → Jun 2019 | melioidosis | Khon Kaen University | Completed | No outcome recorded |
| Phase 4 | NCT00674921 Comparator | Jun 2008 → Jun 2011 | HIV infectious disease | MRC/UVRI and LSHTM Uganda Research Unit | Unknown | No outcome recorded |
| Phase 4 | NCT02028676 Comparator | Mar 2007 → Mar 2012 | HIV infectious disease | Medical Research Council | Completed | No outcome recorded |
| — | NCT00187070 Background | Dec 1997 → Jul 2001 | non-Hodgkin lymphoma | St. Jude Children's Research Hospital | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 42 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Co-trimoxazole | “We randomly assigned eligible participants (1:1) to 6 months of either daily oral co-trimoxazole prophylaxis (given as water-dispersible tablets; 120 mg per day for age <6...” PMID 27265353 ↗ Jun 201640“Isolates were frequently resistant to co-trimoxazole (trimethoprim/sulfamethoxazole) (71.1%) but less so to azithromycin (22.4%), erythromycin (21.1%), chloramphenicol (18.4%),...” PMID 32653726 ↗ Jul 2020 “The study medication Cotrimoxazole (Trimethoprim/Sulfamethoxazole) is a routinely used antimicrobial substance recommended in international and in-house guidelines for...” NCT03633643 ↗ “Cotrimoxazole is a common antibiotic used to treat a variety of illnesses, including urinary and respiratory tract infections and opportunistic pneumocystis pneumonia, and...” NCT04884490 ↗ “HEU children in Botswana were randomly assigned to receive co-trimoxazole (100 mg/20 mg once daily until age 6 months and 200 mg/40 mg once daily thereafter) or placebo from...” PMID 28395844 ↗ May 2017 “Cotrimoxazole (sulfamethoxazole/trimethoprime) 30mg/kg/day (2 divided doses) OR Cefixime 8mg/kg/day (2 divided doses) during 7 days” NCT05544565 ↗ “comparing no prophylaxis with prophylaxis (co-trimoxazole 15 mg/kg per day or co-amoxiclav 15 mg/kg per day) for 12 months.” PMID 18977988 ↗ Nov 2008 “Co-trimoxazole is a sulfamide preparation used to prevent opportunistic infections in HIV-infected patients” PMID 23945130 ↗ Aug 2013 “Isoniazid or placebo given with co-trimoxazole either daily or three times a week.” PMID 17085459 ↗ Nov 2006 “Co-Trimoxazole 960Mg Dispersible Tablet” NCT04395365 ↗ “daily Co-trimoxazole (CTX) prophylaxis” PMID 24830749 ↗ May 2014 |
| Known as | Bactrim Inf Konz | “Single-dose Trimethoprim (TMP)/sulfamethoxazole (SMX, i.e. Cotrimoxazole) perioperative as two ampoules of TMP/SMX 400/80 mg (Bactrim Inf Konz®) solved in 250 ml sodium...” NCT03633643 ↗ |
| Known as | Cotrimoxazole (septrin) | “Cotrimoxazole (septrin)” NCT01701297 ↗ |
| Known as | Cotrimoxazole Forte | “The treatment group will receive Cotrimoxazole Forte 960 mg PO q.d. 4 hours before the biopsy procedure.” NCT04985110 ↗ |
| Known as | CTX | “Long Term Study of 2 Isoniazid (INH) Prophylactic Regimens With Concomitant Cotrimoxazole (CTX) in HIV-infected Children - Impact on Morbidity, Mortality, Bacterial Resistance...” NCT00330304 ↗2“prophylactic cotrimoxazole (CTX) remains widely used to reduce morbidity and mortality in the event of HIV infection among exposed infants” PMID 29119726 ↗ Nov 2017 “CTX” NCT00711906 ↗ |
| Known as | sulfamethoxazole-trimethoprim | “The objective of this study was to evaluate the PK parameters and in vitro PD data on the effective part of co-trimoxazole: sulfamethoxazole. In a prospective PK study in...” PMID 27067336 ↗ Jun 2016 |
| Known as | sulfamethoxazole/trimethoprime | “Cotrimoxazole (sulfamethoxazole/trimethoprime) 30mg/kg/day (2 divided doses) OR Cefixime 8mg/kg/day (2 divided doses) during 7 days” NCT05544565 ↗ |
| Known as | SXT | “The objective of this study was to evaluate the PK parameters and in vitro PD data on the effective part of co-trimoxazole: sulfamethoxazole. In a prospective PK study in...” PMID 27067336 ↗ Jun 2016 |
| Known as | TMP-SMZ | “Co-Trimoxazole; TMP-SMZ” NCT00198627 ↗ |
| Known as | TMP/SMX | “Single-dose Trimethoprim (TMP)/sulfamethoxazole (SMX, i.e. Cotrimoxazole) perioperative as two ampoules of TMP/SMX 400/80 mg (Bactrim Inf Konz®) solved in 250 ml sodium...” NCT03633643 ↗2“followed by oral trimethoprim-sulfamethoxazole (TMP-SMX) for 12 to 20 weeks.” PMID 32725199 ↗ Dec 2021 “Oral Co-trimoxazole (TMP-SMX) 160/800mg twice daily.” NCT04310930 ↗ |
| Known as | trimethoprim sulfamethoxazole | “Isolates were frequently resistant to co-trimoxazole (trimethoprim/sulfamethoxazole) (71.1%) but less so to azithromycin (22.4%), erythromycin (21.1%), chloramphenicol (18.4%),...” PMID 32653726 ↗ Jul 20204“The study medication Cotrimoxazole (Trimethoprim/Sulfamethoxazole) is a routinely used antimicrobial substance recommended in international and in-house guidelines for...” NCT03633643 ↗ “Cotrimoxazole (trimethoprim-sulfamethoxazole) is a relatively 'old' drug commonly used for urinary tract infections.” NCT00427076 ↗ “followed by oral trimethoprim-sulfamethoxazole (TMP-SMX) for 12 to 20 weeks.” PMID 32725199 ↗ Dec 2021 “Cotrimoxazole (trimethoprim sulfamethoxazole)” NCT00137657 ↗ |
| Action | Inhibit | “blocks two steps of folate metabolism” NCT00934492 ↗ |
| Modality | Small molecule | “co-trimoxazole is a sulfamide preparation used to prevent opportunistic infections” PMID 23945130 ↗ Aug 2013 |
| Route | Oral | “twice daily oral cotrimoxazole” NCT00189384 ↗ |