drugset / Trial / NCT06920147
PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network
Phase 4
Not yet recruiting
300 enrolled
The University of Texas Health Science Center, Houston
Surgical Infection Society · collab
RandomizedParallel-groupTriple-blindPrevention
Summary
The purpose of this study is to compare the effectiveness of 2 prophylactic antibiotic regimens, ertapenem and cefazolin with metronidazole, in preventing organ space surgical site infections (OS-SSI) after emergency trauma laparotomy embedded into routine clinical care and to validate a Bayesian OS-SSI risk calculator using Trauma Quality Improvement Program (TQIP) standardized variables
Timeline
- Start
- 2025-05-01
- Primary completion
- 2027-03-31
- Completion
- 2027-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cefazolin | Small molecule | — | Intravenous |
| Subject | Ertapenem | Small molecule | 1 g | Intravenous |
| Subject | Metronidazole | Small molecule | 500 mg | Intravenous |
Indications
No indication recorded.