drugset / Trial / NCT05367479

Antibiotics, Gastric Bypass, and the Microbiome

NCT05367479

Phase 1 Completed 23 enrolled Medical College of Wisconsin
RandomizedParallel-groupOpen-labelBasic science

Summary

This study randomizes patients to two commonly used peri-procedural antibiotics after gastric bypass with the pre and post-operative collection of stool samples, to identify significant differences in relative abundances of gut microbiota phyla, genera and species between the two antibiotic groups used. Gastric bypass may beneficially affect hypertension by altering the post-operative microbiome and specific antibiotics can further enhance the resolution rate by improving microbial diversity and richness.

Timeline

Start
2018-07-18
Primary completion
2020-01-09
Completion
2020-01-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Cefazolin Small molecule Intravenous
Subject Clindamycin Unknown Intravenous