Antibiotic Prophylaxis Before Surgery Versus After Cord Clamping in Elective Cesarean Delivery - a Double-blind, Prospective, Randomized Placebo-controlled Trial

Completed 1112 enrolled Medical University of Vienna

RandomizedParallel-groupQuadruple-blindPrevention

Summary

In this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of administration, ie before skin incision or after umbilical cord clamping

Timeline

Start: 2004-03
Primary completion: 2010-01
Completion: 2010-01

Publications

Witt A, Doner M, Petricevic L, Berger A, Germann P, Heinze G, Tempfer C. Antibiotic prophylaxis before surgery vs after cord clamping in elective cesarean delivery: a double-blind, prospective, randomized, placebo-controlled trial. Arch Surg. 2011 Dec;146(12):1404-9. doi: 10.1001/archsurg.2011.725.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cefazolin	Small molecule	2 g	Intravenous

Indications

No indication recorded.