Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension

Phase 3 Completed 609 enrolled Takeda

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to compare the antihypertensive effect of chlorthalidone vs hydrochlorothiazide when each is used with azilsartan medoxomil, once daily (QD), in participants with moderate to severe essential hypertension.

Timeline

Start: 2009-02
Primary completion: 2009-11
Completion: 2009-11

Publications

Bakris GL, Sica D, White WB, Cushman WC, Weber MA, Handley A, Song E, Kupfer S. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med. 2012 Dec;125(12):1229.e1-1229.e10. doi: 10.1016/j.amjmed.2012.05.023. Epub 2012 Aug 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chlorthalidone	Other / unclassified	12.5 mg	Oral
Subject	Chlorthalidone	Other / unclassified	25 mg	Oral
Subject	Hydrochlorothiazide	Unknown	12.5 mg	Oral
Subject	Hydrochlorothiazide	Unknown	25 mg	Oral
Background	Azilsartan medoxomil	Other / unclassified	40 mg	Oral

Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension

Summary

Timeline

Publications

Drugs

Indications