Drugs / Azilsartan medoxomil
last change Apr 2026 re-read 2 minutes ago

Azilsartan medoxomil

also known as AZL-M · azilsartan · Azilsartan medoximil · Edarbi · TAK-491

Other / unclassified

Developed for
essential hypertension · hypertensive disorder · type 2 diabetes mellitus · chronic kidney disease
Investigated by
Takeda · Arbor Pharmaceuticals, Inc.

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Edarbi 2011-12-07 europa.eu
Approved US (FDA) EDARBI 2011-02-25 fda.gov

Trials 22 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02541669 Nov 2015 → Mar 2017 Takeda Completed No outcome recorded
Phase 1 NCT01078376 May 2010 → Jul 2013 hypertensive disorder Takeda Terminated No outcome recorded
Phase 21 trial
Phase 2 NCT00362115 May → Dec 2006 hypertensive disorder Takeda Completed No outcome recorded
Phase 318 trials
Phase 3 NCT02480764 Aug 2015 → Sep 2017 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT02235909 Mar 2015 → Nov 2019 hypertensive disorder Arbor Pharmaceuticals, Inc. Completed No outcome recorded
Phase 3 NCT02203916 Jul 2014 → Jan 2016 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT01496430 Jan 2012 → May 2013 hypertensive disorder, type 2 diabetes mellitus Takeda Terminated No outcome recorded
Phase 3 NCT01309828 Mar 2011 → Oct 2012 Takeda Completed No outcome recorded
Phase 3 NCT01033071 Jan → Oct 2010 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT00996281 Oct 2009 → Nov 2011 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT00846365 Mar 2009 → Jun 2010 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT00847626 Jan 2009 → May 2010 hypertensive disorder Takeda Completed No outcome recorded
Phase 3 NCT00696436 Apr 2008 → Aug 2009 essential hypertension Takeda Completed No outcome recorded
Phase 41 trial
Phase 4 NCT02517866 Jul 2015 → Nov 2016 essential hypertension, type 2 diabetes mellitus Takeda Completed No outcome recorded
Also used as a comparator or background therapy in 4 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 32 trials
Phase 3 NCT01456169 Comparator Oct 2011 → Dec 2012 essential hypertension Takeda Completed No outcome recorded
Phase 3 NCT00818883 Background Feb → Nov 2009 essential hypertension Takeda Completed No outcome recorded
Phase 41 trial
Phase 4 NCT07547878 Comparator Apr 2026 → Mar 2029 expected chronic kidney disease, type 2 diabetes mellitus Baylor Research Institute Not yet recruiting No outcome recorded
Phase not applicable1 trial
NCT01774591 Comparator Jan 2013 → Nov 2015 hypertensive disorder University of Chicago Completed No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2014-06-18 Takeda Zacras ® Combination Tablets LD and Zacras ® Combination Tablets HD, Fixed-Dose Combination of Azilsartan and Amlodipine, and Azilva ® Tablets 10mg, Treatment for Hypertension, are Now Available in Japan takeda.com

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 30 sources stand behind the page.

FieldValueCited text
Known as azilsartan medoxomil “All subjects were randomized to 80mg azilsartan medoxomil (azilsartan) daily or placebo and followed for six months.” NCT01774591
23

NCT01033071

NCT02203916

NCT00362115

NCT00696436

NCT00591253

NCT01496430

NCT00696384

NCT01078376

NCT00996281

NCT00696241

NCT00760214

NCT00846365

NCT02235909

NCT02480764

NCT02517866

NCT01309828

NCT00591773

NCT01456169

NCT00847626

NCT00591578

NCT00695955

NCT00591266

NCT00818883

Known as azilsartan “All subjects were randomized to 80mg azilsartan medoxomil (azilsartan) daily or placebo and followed for six months.” NCT01774591
Known as Azilsartan medoximil ClinicalTrials.gov intervention name — accepted as the source's own label NCT01774591
Known as AZL-M “A phase 3, 26-week, open-label, titrate-to-target study (n=418) assessed the safety of azilsartan medoxomil (AZL-M) alone and with chlorthalidone (CLD), followed by a 6-week,...” PMID 25619410 Jan 2015
3

“Azilsartan medoxomil (AZL-M) is a unique angiotensin II receptor blocker (ARB) under development for the treatment of hypertension.” PMID 21762358 Jun 2011

“Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker” PMID 32769878 Aug 2020

“azilsartan medoxomil (AZL-M) 40 mg” PMID 29445520 Feb 2018

Known as Edarbi ClinicalTrials.gov intervention name — accepted as the source's own label NCT07547878
Known as TAK-491 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02541669
Action Inhibit “angiotensin II type 1 receptor antagonist” NCT00362115
Modality Other / unclassified “TAK-491 (azilsartan medoxomil) is an angiotensin II receptor blocker” NCT00591773
Route Oral orally” NCT00362115