Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)

Phase 3 Completed 347 enrolled Astellas Pharma Inc

RandomizedParallel-groupQuadruple-blindDiagnostic

Summary

Observe whether the administration of caffeine prior to regadenoson will affect the interpretation of test results in subjects with coronary artery disease (CAD) undergoing SPECT MPI

Timeline

Start: 2009-03-24
Primary completion: 2010-07-15
Completion: 2010-07-15

Outcome

Met primary endpoint

registry analysis (unspecified test); Placebo Plus Regadenoson vs Caffeine 200 mg Plus Regadenoson vs Caffeine 400 mg Plus Regadenoson; p <0.001; ANCOVA NCT00826280 ↗

Publications

Tejani FH, Thompson RC, Iskandrian AE, McNutt BE, Franks B. Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: rationale and design of a prospective, randomized, multicenter study. J Nucl Cardiol. 2011 Feb;18(1):73-81. doi: 10.1007/s12350-010-9311-6. Epub 2010 Nov 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Caffeine	Small molecule	200 mg	Oral
Subject	Caffeine	Small molecule	400 mg	Oral
Background	Regadenoson	Diagnostic / imaging agent	0.4 mg	Intravenous