Drugs / Regadenoson

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) LEXISCAN 2017-01-17 fda.gov
Approved EU (EMA) Rapiscan 2010-09-06 europa.eu
Approved US (FDA) LEXISCAN 2008-04-10 fda.gov

Trials 31 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT04521569 Jun 2020 → Jun 2024 University of Maryland, Baltimore Completed No outcome recorded
Phase 0 NCT02389738 Feb 2015 → Feb 2016 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 0 NCT00881218 Jun 2009 → Dec 2011 myocardial ischemia Washington University School of Medicine Completed No outcome recorded
Phase 15 trials
Phase 1 NCT03971734 Dec 2019 → Apr 2022 anaplastic astrocytoma, anaplastic oligodendroglioma, glioblastoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Terminated No outcome recorded
Phase 1 NCT03072589 Nov 2017 → Aug 2021 Christine Lau, MD Unknown No outcome recorded
Phase 1 NCT01918995 May → Aug 2013 Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 1 NCT01161121 Jul 2010 → Apr 2013 coronary artery disorder St. Louis University Completed No outcome recorded
Phase 1 NCT01085201 Apr 2010 → Feb 2013 sickle cell disease Dana-Farber Cancer Institute Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT04604782 May 2021 → Dec 2026 expected coronary artery disorder, myocardial ischemia GE Healthcare Recruiting No outcome recorded
Phase 1/2 NCT04606069 May 2021 → Apr 2023 COVID-19, pneumonitis University of Maryland, Baltimore Completed No outcome recorded
Phase 23 trials
Phase 2 NCT03090087 Mar → Nov 2017 retinal artery occlusion University of Aarhus Unknown No outcome recorded
Phase 2 NCT01710254 Jan 2013 → Oct 2016 atrial fibrillation, coronary artery disorder University of Utah Completed No outcome recorded
Phase 2 NCT00907764 Apr 2009 → Apr 2010 coronary artery disorder Gilead Sciences Terminated No outcome recorded
Phase 34 trials
Phase 3 NCT01489176 Jul 2012 → Apr 2014 coronary artery disorder, myocardial disorder University of Nebraska Completed No outcome recorded
Phase 3 NCT01618669 Jun 2012 → Dec 2014 coronary artery disorder Astellas Pharma Global Development, Inc. Completed No outcome recorded
Phase 3 NCT00208312 Apr 2004 → Jun 2005 coronary artery disorder Gilead Sciences Completed No outcome recorded
Phase 3 NCT00208299 Oct 2003 → Aug 2006 coronary artery disorder Gilead Sciences Completed No outcome recorded
Phase 47 trials
Phase 4 NCT02589977 Nov 2015 → Jan 2020 diastolic heart failure, hypertensive disorder Marvin W. Kronenberg, M.D. Completed No outcome recorded
Phase 4 NCT02115308 Sep 2014 → Jan 2018 coronary artery disorder Timothy M. Bateman Completed No outcome recorded
Phase 4 NCT01446094 Aug 2011 → Jun 2018 coronary artery disorder Dipan Shah Unknown No outcome recorded
Phase 4 NCT01019486 Nov 2009 → Dec 2011 coronary artery disorder, type 1 diabetes mellitus University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT00863707 Apr → Dec 2009 chronic kidney disease, coronary artery disorder Astellas Pharma Inc Completed No outcome recorded
Phase 4 NCT00862641 Apr → Oct 2009 asthma, chronic obstructive pulmonary disease, coronary artery disorder Astellas Pharma Inc Completed No outcome recorded
Phase 4 NCT00871260 Apr 2009 → Jun 2014 coronary artery disorder University of Chicago Completed No outcome recorded
Phase not applicable7 trials
NCT02220634 Aug 2014 → May 2017 pulmonary hypertension National Jewish Health Terminated No outcome recorded
NCT01842035 Feb 2013 → Apr 2020 sudden arrhythmia death syndrome, systolic heart failure University of Alabama at Birmingham Completed No outcome recorded
NCT01566890 Jul 2012 → Jul 2019 sickle cell disease Versiti Blood Health Completed No outcome recorded
NCT01482169 Mar 2012 → May 2014 coronary artery disorder Ochsner Health System Completed No outcome recorded
NCT01021618 Jan 2010 → Mar 2012 coronary artery disorder, myocardial ischemia Hartford Hospital Completed No outcome recorded
NCT01026012 Dec 2009 → Sep 2010 University of Maryland, Baltimore Completed No outcome recorded
NCT00859833 Feb 2009 → Jul 2010 obesity disorder University of Utah Completed No outcome recorded
Also used as a comparator or background therapy in 28 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT04600115 Background Mar 2017 → Mar 2027 expected MRI defined brain infarct University of Utah Recruiting No outcome recorded
Phase 0 NCT00763035 Comparator Jan 2009 → Dec 2010 asthma, chronic obstructive pulmonary disease, intermediate coronary syndrome Wake Forest University Health Sciences Terminated No outcome recorded
Phase 12 trials
Phase 1 NCT01433705 Background Nov 2011 → Jan 2018 heart disorder University of Michigan Completed No outcome recorded
Phase 1 NCT00837369 Background Apr 2009 → Mar 2011 coronary artery disorder University of Nebraska Completed No outcome recorded
Phase 26 trials
Phase 2 NCT05583721 Background Oct 2023 → Sep 2027 expected sickle cell disease St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 2 NCT03103061 Background Feb 2016 → Jun 2018 coronary artery disorder Medical University of South Carolina Completed No outcome recorded
Phase 2 NCT01840696 Background Oct 2013 → May 2014 coronary artery disorder Emory University Withdrawn No outcome recorded
Phase 2 NCT01788631 Comparator Jul 2013 → Nov 2016 sickle cell disease Dana-Farber Cancer Institute Completed No outcome recorded
Phase 2 NCT01655043 Background Sep 2012 → Feb 2014 myocardial ischemia Northwestern University Completed No outcome recorded
Phase 33 trials
Phase 3 NCT03354273 Background Jun 2018 → May 2022 coronary artery disorder GE Healthcare Completed No outcome recorded
Phase 3 NCT01809743 Comparator Jan → Oct 2013 coronary artery disorder Lokien van Nunen Completed No outcome recorded
Phase 3 NCT00826280 Background Mar 2009 → Jul 2010 coronary artery disorder Astellas Pharma Inc Completed No outcome recorded
Phase 47 trials
Phase 4 NCT03102125 Background Oct 2019 → Jan 2027 expected transplant rejection Paul Kim Recruiting No outcome recorded
Phase 4 NCT03249272 Comparator Sep 2017 → Mar 2019 coronary microvascular disorder, dilated cardiomyopathy, hypertrophic cardiomyopathy Duke University Terminated No outcome recorded
Phase 4 NCT02597543 Background Nov 2015 → Jun 2016 acute transplant rejection, chronic transplant rejection Paul Kim Completed No outcome recorded
Phase 4 NCT02130453 Background Sep 2014 → Jun 2024 ischemic disease M.D. Anderson Cancer Center Completed No outcome recorded
Phase 4 NCT01919450 Comparator Jul 2013 → Apr 2016 Timothy M. Bateman, MD Completed No outcome recorded
Phase not applicable8 trials
NCT06854458 Background Jun 2025 → Jan 2029 expected ischemic disease Brigham and Women's Hospital Recruiting No outcome recorded
NCT04316676 Background Jun 2021 → Sep 2024 coronary artery disorder Emory University Completed No outcome recorded
NCT02560467 Background Dec 2015 → Sep 2019 hypertrophic cardiomyopathy Oregon Health and Science University Unknown No outcome recorded
NCT01969916 Background Jun 2014 → Jun 2018 coronary artery disorder University of Chicago Completed No outcome recorded
NCT01949844 Background May 2014 → Jan 2017 coronary artery disorder Daniel S. Berman Completed No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2009-05-28 Gilead Sciences Gilead Sciences' Marketing Authorisation Application for Regadenoson Validated by European Medicines Agency gilead.com

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 60 sources stand behind the page.

FieldValueCited text
Known as regadenoson “Pharmacologic stress agents were restricted to the following 3 agents, as permitted by local marketing authorisations and availability: adenosine, dipyridamole, and regadenoson.” NCT03354273
55

“All participants will receive vasodilator (regadenoson or adenosine depending on local site practice).” NCT06854458

“Vasodilator stress during MCE imaging will be performed using regadenoson at FDA-approved doses.” NCT02560467

NCT00826280

NCT01710254

NCT01026012

NCT00862641

NCT02597543

NCT00857792

NCT03090087

NCT01489176

NCT03072589

NCT01655043

NCT01019486

NCT01334918

NCT01969916

NCT01809743

NCT02220634

NCT04316676

NCT01482169

NCT01618669

NCT02608944

NCT00763035

NCT04606069

NCT01919450

NCT04604782

NCT01433705

NCT04521569

NCT01788631

NCT03971734

NCT01949844

NCT01779869

NCT01021618

NCT01842035

NCT02115308

NCT02130453

NCT00871260

NCT00859833

NCT00881218

NCT01840696

NCT00837369

NCT01918995

NCT01161121

NCT00208299

NCT01109992

NCT00208312

NCT04600115

NCT03102125

NCT02589977

NCT01370265

NCT01446094

NCT03249272

NCT02389738

NCT01566890

NCT00863707

NCT00907764

Known as Lexiscan “This study will evaluate the maximum safe dose and duration of regadenoson (Lexiscan) that can be given to people who are having a lung transplant.” NCT03072589
8

“Regadenoson is approved in the US under the brand name Lexiscan for myocardial perfusion imaging.” NCT00907764

“Regadenoson (Lexiscan, Astellas), a recently FDA approved A2A receptor agonist” NCT00881218

“Patients will be given a single dose of Lexiscan (0.4 mg, iv bolus)” NCT01969916

“Astellas Pharma, Tokyo, Japan (Lexiscan [regadenoson])” PMID 36117179 Sep 2022

“Regadenoson (Lexiscan)” NCT01109992

NCT03103061

NCT05583721

NCT01085201

Known as Rapiscan “Regadenoson (Rapiscan)” NCT01809743
Known as Regadenoson (Lexiscan) Regadenoson (Lexiscan)NCT01019486
Action Activate “regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist” NCT00208299
Modality Diagnostic / imaging agent “as an imaging agent” NCT00763035
Route Intravenous “0.4 mg, bolus intravenous injection” NCT00208299