drugset / Trial / NCT00830037

A Clinical Trial of Oral Versus IV Iron in Patients With Chronic Kidney Disease

NCT00830037

RandomizedParallel-groupOpen-labelTreatment

Summary

The long-term goal is to assess the fall in kidney function measured by glomerular filtration rate (GFR) when patients with chronic kidney disease (CKD) are exposed to intravenous iron (IVIR). We hypothesize that in subjects with mild to moderate CKD, infusion of intravenous iron (IVIR), will generate oxidative stress and cause an inflammatory response that will be associated with a more rapid decline in glomerular filtration rate (GFR) compared to oral iron.

Timeline

Start
2008-08
Primary completion
2014-11
Completion

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ferrous Sulfate Diagnostic / imaging agent 325 mg Oral
Subject Iron sucrose Unknown 200 mg Intravenous