drugset / Trial / NCT00830037
A Clinical Trial of Oral Versus IV Iron in Patients With Chronic Kidney Disease
Phase 4
Terminated
136 enrolled
Indiana University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The long-term goal is to assess the fall in kidney function measured by glomerular filtration rate (GFR) when patients with chronic kidney disease (CKD) are exposed to intravenous iron (IVIR). We hypothesize that in subjects with mild to moderate CKD, infusion of intravenous iron (IVIR), will generate oxidative stress and cause an inflammatory response that will be associated with a more rapid decline in glomerular filtration rate (GFR) compared to oral iron.
Timeline
- Start
- 2008-08
- Primary completion
- 2014-11
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ferrous Sulfate | Diagnostic / imaging agent | 325 mg | Oral |
| Subject | Iron sucrose | Unknown | 200 mg | Intravenous |