drugset / Trial / NCT00830492
Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist
RandomizedParallel-groupSingle-blindTreatment
Summary
Objective: To compare the efficacy of using mild ovarian stimulation protocol and conventional stimulation protocol in IVF outcome. Design: Prospective randomized trial Setting: University IVF setting. Patient(s): The study compromised a total 200 subinfertile couple that women had regulary menstruation. Intervention(s): Patients were randomized to treatment clomiphene citrate, gonadotropin and GnRH antagonist (100 patients) or GnRH agonist and gonadotropin ( 100 patients). Main outcome measure: Clinical pregnancy rate. Key Words: clomiphene citrate, GnRH agonist, GnRH antagonist, in vitro fertilization, pregnancy rate.
Timeline
- Start
- 2008-01
- Primary completion
- 2008-12
- Completion
- 2008-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clomiphene Citrate | Other / unclassified | 100 mg | — |
| Subject | Ganirelix | Protein / enzyme biologic | — | — |
| Comparator | buserelin | Unknown | 250 ug | Subcutaneous |
| Subject | human menopausal gonadotropin | Unknown | 75 iu | — |
| Comparator | recombinant FSH | Protein / enzyme biologic | 150 iu | Subcutaneous |
| Comparator | recombinant FSH | Protein / enzyme biologic | 225 iu | Subcutaneous |