Comparison of N2O Inhalation and Ketamine in Pediatric PSA

Phase 4 Completed 32 enrolled Seoul National University Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

* Ketamine provides effective and relatively safe sedation analgesia for primary closure of lacerated pediatric patients * However, deep sedation and adverse effects suggest the opportunity to develop alternative strategies * We compared the efficacy and adverse effects of ketamine to those of N2O gas for analgesia and anxiolysis during primary repair of lacerated pediatric patients

Timeline

Start: 2009-01
Primary completion: 2009-12
Completion: 2009-12

Outcome

Met primary endpoint

paper N(2)O group compared with those in the ketamine group (median [interquartile range (IQR)], 0.0 minutes, [0.0-4.0 minutes] vs 21.5 minutes [12.5-37.5 minutes], P < 0.05) PMID 23187987 ↗

Publications

Lee JH, Kim K, Kim TY, Jo YH, Kim SH, Rhee JE, Heo CY, Eun SC. A randomized comparison of nitrous oxide versus intravenous ketamine for laceration repair in children. Pediatr Emerg Care. 2012 Dec;28(12):1297-301. doi: 10.1097/PEC.0b013e3182768a86.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	2 mg/kg	Intravenous
Subject	Nitrous Oxide	Other / unclassified	50 %	Inhaled
Subject	Nitrous Oxide	Other / unclassified	70 %	Inhaled

Indications

No indication recorded.