drugset / Trial / NCT00842556
Pharmacokinetic Drug Interaction Study of Dapagliflozin and Glimepiride or Sitagliptin in Healthy Subjects
RandomizedCrossoverOpen-label
Summary
To assess the effect of glimepiride on the PK of dapagliflozin and the effect of dapagliflozin on the PK of glimepiride, when co-administered in healthy subjects (Phase A) and to assess the effect of sitagliptin on the PK of dapagliflozin and the effect of dapagliflozin on the PK of sitagliptin, when co-administered in healthy subjects (Phase B)
Timeline
- Start
- 2009-03
- Primary completion
- 2009-05
- Completion
- 2009-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dapagliflozin | Small molecule | 20 mg | Oral |
| Comparator | Glimepiride | Small molecule | 4 mg | Oral |
| Comparator | Sitagliptin | Small molecule | 100 mg | Oral |