drugset / Trial / NCT00844311
Supplementation With Human Chorionic Gonadotropin (hCG) During Controlled Ovarian Stimulation With Recombinant Follicle-stimulating Hormone (FSH) for In Vitro Fertilisation
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this trial is to study whether addition of different doses of human chorionic gonadotropins during controlled ovarian stimulation for patients undergoing IVF will improve the number of top-quality embryos.
Timeline
- Start
- 2009-02
- Primary completion
- 2010-06
- Completion
- 2010-06
Outcome
Met primary endpoint
paper The mean numbers of top-quality embryos per patient were D0: 0.8 ± 1.2, D50: 0.5 ± 0.7, D100: 1.2 ± 1.7 and D150: 1.5 ± 1.7 (P= 0.04). PMID 22791754 ↗
Publications
- Thuesen LL, Andersen AN, Loft A, Smitz J. Intrafollicular endocrine milieu after addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization. J Clin Endocrinol Metab. 2014 Feb;99(2):517-26. doi: 10.1210/jc.2013-1528. Epub 2013 Dec 2.
- Thuesen LL, Loft A, Egeberg AN, Smitz J, Petersen JH, Andersen AN. A randomized controlled dose-response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization. Hum Reprod. 2012 Oct;27(10):3074-84. doi: 10.1093/humrep/des256. Epub 2012 Jul 12.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | human chorionic gonadotropin | Protein / enzyme biologic | 50 iu | — |
| Subject | human chorionic gonadotropin | Protein / enzyme biologic | 100 iu | — |
| Subject | human chorionic gonadotropin | Protein / enzyme biologic | 150 iu | — |
| Background | Recombinant human follicle stimulating hormone (r-hFSH) | Protein / enzyme biologic | 150 iu | — |