drugset / Trial / NCT00849368
Azathioprine & Allopurinol in Inflammatory Bowel Disease Patients
NaSingle-groupOpen-labelTreatment
Summary
Main Study Objectives: The study is conducted to * evaluate the minimal allopurinol and azathioprine doses that, in combination, produce therapeutic 6-TGN levels * evaluate the safety and tolerability of the different allopurinol/azathioprine dose levels * assess if concomitant allopurinol affects TPMT activity * assess the clinical efficacy of concomitant allopurinol-azathioprine therapy in the included patients
Timeline
- Start
- 2009-01
- Primary completion
- 2011-09
- Completion
- 2011-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Allopurinol | Small molecule | 100 mg | Oral |
| Subject | Azathioprine | Small molecule | 25 mg | Oral |
| Subject | Azathioprine | Small molecule | 50 mg | Oral |