Preventing Propofol-associated Injection Pain

Phase 4 Completed 156 enrolled Benaroya Research Institute

RandomizedParallel-groupDouble-blindTreatment

Summary

Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.

Timeline

Start: 2008-01
Primary completion: 2009-03
Completion: 2009-04

Publications

Walker BJ, Neal JM, Mulroy MF, Humsi JA, Bittner RC, McDonald SB. Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial. Reg Anesth Pain Med. 2011 Jan-Feb;36(1):41-5. doi: 10.1097/AAP.0b013e31820306da.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Lidocaine	Other / unclassified	50 mg	Intravenous
Comparator	Propofol	Small molecule	50 mg	Intravenous

Indications

No indication recorded.