Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine

Phase 4 Terminated 320 enrolled London North West Healthcare NHS Trust Medical Research Council CTU · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The use of oral ibuprofen combined with Opioid (Morphine or Diamorphine) administered through patient controlled analgesia (PCA) will be clinically effective for acute pain crisis in adults with sickle cell disease (SCD).

Timeline

Start: 2011-03
Primary completion: 2014-03
Completion: 2014-08

Outcome

Outcome not reported

Stopped (Enrollment): “The funding withdrawal and early termination of the trial is based upon lack of suitable recruitment figures in order to reach the required trial endpoints.”

Publications

Cho G, Anie KA, Buckton J, Kiilu P, Layton M, Alexander L, Hemmaway C, Sutton D, Amos C, Dore CJ, Kahan B, Meredith S. SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt. BMJ Open. 2016 Jun 9;6(6):e011276. doi: 10.1136/bmjopen-2016-011276.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ibuprofen	Small molecule	800 mg	Oral
Comparator	Diacetylmorphine	Small molecule	—	Intravenous
Comparator	Morphine	Other / unclassified	—	Intravenous