drugset / Trial / NCT00893269
The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
Phase 1
Completed
36 enrolled
Johns Hopkins University
Food and Drug Administration (FDA) · collabNational Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverDouble-blindBasic science
Summary
Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine whether a medication approved for treating insomnia can help restore normal sleep function during brief periods of abstinence.
Timeline
- Start
- 2008-10
- Primary completion
- 2010-10
- Completion
- 2010-10
Publications
- Vandrey R, Umbricht A, Strain EC. Increased blood pressure after abrupt cessation of daily cannabis use. J Addict Med. 2011 Mar;5(1):16-20. doi: 10.1097/ADM.0b013e3181d2b309.
- Vandrey R, Smith MT, McCann UD, Budney AJ, Curran EM. Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal. Drug Alcohol Depend. 2011 Aug 1;117(1):38-44. doi: 10.1016/j.drugalcdep.2011.01.003. Epub 2011 Feb 5.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Eszopiclone | Small molecule | — | Oral |
| Subject | Ramelteon | Unknown | — | — |
| Subject | Zolpidem | Small molecule | — | — |