A Study of Different Use Regimens Using Two Acne Treatments

Phase 4 Completed 247 enrolled Bausch Health Americas, Inc.

RandomizedParallel-groupSingle-blindTreatment

Summary

A study to determine if using 2 acne products in the morning is as safe and efficacious as using one product in the morning and one product in the evening.

Timeline

Start: 2009-02
Primary completion: 2009-09
Completion: 2009-09

Outcome

Met primary endpoint

paper The morning/morning regimen was determined to be non-inferior to the morning/evening regimen in reduction of total acne lesions. PMID 20677537 ↗

Publications

Results Pariser D, Bucko A, Fried R, Jarratt MT, Kempers S, Kircik L, Lucky AW, Rafal E, Rendon M, Weiss J, Wilson DC, Rossi AB, Ramaswamy R, Nighland M. Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. J Drugs Dermatol. 2010 Jul;9(7):805-13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Benzoyl Peroxide	Other / unclassified	5 %	Topical
Subject	Tretinoin	Unknown	0.04 %	Topical