Drugs / Benzoyl Peroxide
last change Jan 2026 re-read 2 minutes ago

Benzoyl Peroxide

Other / unclassified

Developed for
acne · rosacea · infectious disease · molluscum contagiosum · periprosthetic joint infection · skin disorder · skin infection · hidradenitis suppurativa
Investigated by
Galderma R&D · GlaxoSmithKline · Stiefel, a GSK Company · Sun Pharmaceutical Industries, Inc. · Bausch Health Americas, Inc. · Sol-Gel Technologies, Ltd.
+41 more · Northwestern University · Padagis LLC · Wake Forest University · Actavis Inc. · Allergan · Balgrist University Hospital · Beth Israel Deaconess Medical Center · Cell Pharma · Colorado Joint Replacement · Galderma Brasil Ltda. · Glenmark Pharmaceuticals Ltd. India · Greg Bew · Hospital Civil de Guadalajara · Hospital del Mar · Icahn School of Medicine at Mount Sinai · Marmara University · McLaren Health Care · Medicis Global Service Corporation · Merete Haedersdal · Nantes University Hospital · Ortho Dermatologics · Proinnovera GmbH · Quintiles, Inc. · Rho, Inc. · Sanofi · Sebacia, Inc. · Seoul National University Hospital · Topix Pharmaceuticals · Treatment and Diagnostic Center of Private Enterprise "Asklepiy" · University of Guadalajara · University of Maryland, Baltimore · University of Missouri-Columbia · University of Oklahoma · University of Southern California · University of Washington · Watson Laboratories, Inc. · Yardley Dermatology Associates · Zeichner, Joshua, M.D. · Zurita Laboratorio Farmaceutico Ltda. · Zydus Lifesciences Limited · delta medical promotions ag

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) BENZAMYCIN 1984-10-26 fda.gov

Trials 78 · started per year

today
US approved 1984
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198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT06673641 May → Sep 2024 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT05675501 Jun 2020 → Jul 2021 rosacea Sol-Gel Technologies, Ltd. Completed No outcome recorded
Phase 1 NCT02709902 Sep 2015 → Feb 2016 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT02578043 Apr → Aug 2015 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT01769235 Nov 2012 → Sep 2013 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT01742637 Oct 2012 → Feb 2014 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT01769664 Sep 2012 → Jun 2013 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT01132443 May → Jun 2010 acne Stiefel, a GSK Company Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03076320 Mar 2017 → Jan 2019 acne University of Guadalajara Completed No outcome recorded
Phase 25 trials
Phase 2 NCT07032649 Jan 2026 → Jan 2027 expected Greg Bew Not yet recruiting No outcome recorded
Phase 2 NCT04892706 Jun 2021 → Sep 2022 acne Bausch Health Americas, Inc. Completed No outcome recorded
Phase 2 NCT03257202 Sep 2017 → Jan 2018 University of Southern California Completed No outcome recorded
Phase 2 NCT03122457 Jan 2017 → Jul 2018 actinic keratosis Icahn School of Medicine at Mount Sinai Completed No outcome recorded
Phase 2 NCT00713609 Jun 2008 → Mar 2009 acne Stiefel, a GSK Company Completed No outcome recorded
Phase 324 trials
Phase 3 NCT05536882 May 2022 → Oct 2023 molluscum contagiosum University of Oklahoma Withdrawn No outcome recorded
Phase 3 NCT04028401 Jun 2020 → Jun 2029 expected skin infection Nantes University Hospital Recruiting No outcome recorded
Phase 3 NCT03761784 Dec 2018 → Dec 2019 acne Sol-Gel Technologies, Ltd. Completed No outcome recorded
Phase 3 NCT03564145 Sep 2018 → Nov 2019 rosacea Sol-Gel Technologies, Ltd. Terminated No outcome recorded
Phase 3 NCT03448939 Jun 2018 → May 2019 rosacea Sol-Gel Technologies, Ltd. Completed No outcome recorded
Phase 3 NCT02932267 Feb 2017 → Jan 2018 acne Galderma R&D Completed No outcome recorded
Phase 3 NCT02651220 Nov 2015 → Apr 2016 acne Actavis Inc. Completed No outcome recorded
Phase 3 NCT02515305 Jul 2015 → Apr 2016 acne Padagis LLC Completed No outcome recorded
Phase 3 NCT02465632 Apr → Nov 2015 acne Glenmark Pharmaceuticals Ltd. India Completed No outcome recorded
Phase 3 NCT02005666 Nov 2013 → Sep 2016 acne Zydus Lifesciences Limited Completed No outcome recorded
Phase 432 trials
Phase 4 NCT05676411 Jun 2024 → Jul 2025 periprosthetic joint infection University of Missouri-Columbia Withdrawn No outcome recorded
Phase 4 NCT06336629 Nov 2023 → Jul 2024 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 4 NCT05446402 Jun 2022 → May 2023 acne Northwestern University Completed No outcome recorded
Phase 4 NCT04548349 Apr 2021 → Aug 2022 acne Beth Israel Deaconess Medical Center Completed No outcome recorded
Phase 4 NCT03849885 Feb 2019 → Dec 2023 osteoarthritis Colorado Joint Replacement Unknown No outcome recorded
Phase 4 NCT04021524 Sep 2018 → May 2019 acne University of Washington Completed No outcome recorded
Phase 4 NCT03563365 Jun 2018 → Mar 2021 acne Yardley Dermatology Associates Terminated No outcome recorded
Phase 4 NCT02899000 Jul 2016 → Mar 2017 acne Galderma R&D Completed No outcome recorded
Phase 4 NCT02735421 May 2016 → Jun 2017 acne Galderma R&D Completed No outcome recorded
Phase 4 NCT02557399 Oct → Dec 2015 acne GlaxoSmithKline Completed No outcome recorded
Phase not applicable8 trials
NCT05355844 May 2022 → May 2023 rotator cuff syndrome, spondylosis Hospital del Mar Unknown No outcome recorded
NCT05855629 Feb 2022 → Jun 2023 acne Treatment and Diagnostic Center of Private Enterprise "Asklepiy" Unknown No outcome recorded
NCT03949751 Nov 2018 → Apr 2020 Balgrist University Hospital Completed No outcome recorded
NCT03573115 Jan → Jul 2018 acne Merete Haedersdal Completed No outcome recorded
NCT02219776 Sep 2015 → Jun 2021 infectious disease McLaren Health Care Completed No outcome recorded
NCT02510144 Aug 2015 → Jul 2018 University of Maryland, Baltimore Completed No outcome recorded
NCT02192632 Jan 2014 → Feb 2015 acne Seoul National University Hospital Completed No outcome recorded
NCT00787943 May 2008 → Jan 2009 acne Northwestern University Completed No outcome recorded
Also used as a comparator or background therapy in 39 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT04206631 Comparator Apr → Sep 2015 acne Indonesia University Completed No outcome recorded
Phase 1 NCT02595034 Comparator Jan → Oct 2015 acne Sun Pharmaceutical Industries, Inc. Completed No outcome recorded
Phase 1 NCT01428466 Comparator Nov 2010 → Feb 2011 acne GlaxoSmithKline Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01106807 Comparator Apr → Sep 2010 acne Galderma R&D Completed No outcome recorded
Phase 310 trials
Phase 3 NCT01880320 Comparator Jul 2013 → Mar 2014 acne Galderma R&D Completed No outcome recorded
Phase 3 NCT01915732 Comparator Apr 2013 → Apr 2014 acne GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT01138514 Comparator Oct 2009 → Oct 2010 acne Padagis LLC Completed No outcome recorded
Phase 3 NCT01014689 Comparator Aug 2009 → Apr 2010 acne Galderma R&D Completed No outcome recorded
Phase 3 NCT00883233 Comparator Apr → Sep 2009 acne Galderma R&D Completed No outcome recorded
Phase 415 trials
Phase 4 NCT04300010 Comparator Oct 2020 → Jan 2021 acne University of Wisconsin, Madison Completed No outcome recorded
Phase 4 NCT04000347 Comparator Jun 2019 → Apr 2022 Mahidol University Withdrawn No outcome recorded
Phase 4 NCT03832647 Background Feb 2019 → Feb 2020 acne Vichy Laboratoires Completed No outcome recorded
Phase 4 NCT05096312 Comparator Dec 2018 → Jul 2019 acne East Avenue Medical Center, Philippines Completed No outcome recorded
Phase 4 NCT02731105 Comparator Feb 2015 → Feb 2017 acne GWT-TUD GmbH Completed No outcome recorded
Phase not applicable10 trials
NCT03650881 Comparator Aug 2018 → Feb 2020 acne NYU Langone Health Withdrawn No outcome recorded
NCT02698436 Comparator Mar → Aug 2016 acne Johnson & Johnson Consumer and Personal Products Worldwide Completed No outcome recorded
NCT01818167 Comparator Jan 2013 → Dec 2014 hidradenitis suppurativa Henry Ford Health System Completed No outcome recorded
NCT01472900 Comparator Oct 2010 → Apr 2012 acne Chulalongkorn University Completed No outcome recorded
NCT01237821 Comparator Oct 2010 → Aug 2011 acne Milton S. Hershey Medical Center Completed No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2021-12-01 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Launch of an Authorized Generic of Epiduo® Forte Gel (adapalene and benzoyl peroxide gel 0.3%/2.5%), in the U.S. tevapharm.com
2017-07-28 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Launch of Generic Epiduo® in the United States tevapharm.com

Evidence & citations 75 cited values

Every value below carries the sentence it was read from. 126 sources stand behind the page.

FieldValueCited text
Known as benzoyl peroxide “METHODS: This 16-week, two-center, investigator-blinded, randomized, parallel-group study evaluated the antimicrobial efficacy of clindamycin phosphate 1%/benzoyl peroxide 5%...” PMID 20214175 Feb 2010
114

“Participants with moderate and severe acne will be treated once a day (at night) on the face and superior back with a smooth layer (standard finger tip unit 0.5 g for an area...” NCT03076320

“OBJECTIVE: The aim of this study was to compare the efficacy and safety of clindamycin (1%) and benzoyl peroxide (5%) (CDP/BPO) gel once daily vs. clindamycin (1%) (CDP)...” PMID 27075705 Apr 2016

“Objective: Evaluate subject-reported outcomes after treatment with adapalene 0.3%/ benzoyl peroxide 2.5% gel (0.3% A/BPO) in subjects with SOC and moderate to severe acne vulgaris.” PMID 31251543 Jun 2019

“Participants applied Adapalene 0.3% - Benzoyl peroxide (BPO) 2.5% gel (ABPO Forte) topically to the affected areas once daily for 24 weeks in Part 1 and for 48 weeks in Part 2.” NCT02735421

“Clindamycin phosphate (CLIN) 1.2%/adapalene (ADAP) 0.15%/benzoyl peroxide (BPO) 3.1% gel (CAB) is the only triple-combination topical approved for acne.” PMID 40377868 May 2025

“gel formulation containing a combination of clindamycin phosphate (equivalent to 1% clindamycin) and benzoyl peroxide (5%) once daily” NCT00160394

Benzoyl peroxide has antimicrobial and anti inflammatory properties and is often considered an important component of acne treatment.” NCT01706263

“Evaluation of Efficacy and Safety of Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in the Treatment of Acne Vulgaris” NCT01149330

“A new formulation of benzoyl peroxide (E-BPO cream, 5%) entraps benzoyl peroxide (BPO) in silica microcapsules.” PMID 37636253 Aug 2023

“Adapalene 0.1% / Benzoyl Peroxide (quoted as BPO) 2.5% Gel associated with Doxycycline Hyclate 100 mg Tablets” NCT00688064

“Once-daily application of fixed dose of adapalene 0.1% and benzoyl peroxide 2.5% in an aqueous based gel.” NCT01522456

“Encapsulated Benzoyl Peroxide (E-BPO) and Encapsulated Tretinoin (E-ATRA) Cream, (E-BPO/E-ATRA Cream)” NCT03761784

“fixed-combination adapalene plus benzoyl peroxide (A/BPO) is a first-line recommended acne therapy” PMID 28686776 Jun 2017

“Duac® fixed dose combination gel containing clindamycin phosphate 1.2% and benzoyl peroxide 3%.” NCT02557399

“Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel standard daily overnight application for 12 week” NCT00883233

“Adapalene 0.1% / Benzoyl Peroxide (BPO) 2.5% Gel associated with Lymecycline 300mg Capsules” NCT01014689

“fixed dose combination of 0.3% adapalene with 2.5% benzoyl peroxide (A/BPO gel 0.3%/2.5%)” PMID 28686775 Jun 2017

“GK530G is the fixed-dose combination gel of Adapalene and Benzoyl Peroxide, BPO” NCT01910064

Benzoyl Peroxide (BPO) wash will be used once daily in the morning for 28 days” NCT00891982

“fixed-dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin” PMID 24934963 Oct 2014

“Topical gel in 1 g containing clindamycin 10 mg and benzoyl peroxide 30 mg” NCT01445301

“Dose or Concentration:Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel.” NCT01188538

“1. Renewing Cleanser (Active ingredient: 2.5% Benzoyl Peroxide)” NCT05446402

benzoyl peroxide gel 2.5% on face in the morning and afternoon” NCT04206631

“Topical, 1% Clindamycin/5% Benzoyl Peroxide, BID, 12 weeks” NCT01237821

“containing 3% benzoyl peroxide (BPO) and 1% clindamycin” NCT02058628

“Adapalene/Benzoyl Peroxide (BPO) Gel Pump (once daily)” NCT01951417

“microencapsulated benzoyl peroxide cream, 5%” PMID 37636251 Aug 2023

“Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel” NCT00441415

“5% benzoyl peroxide), applied once daily” NCT00807014

“100 per arm Adapalene/ Benzoyl PeroxideNCT03832647

“Clindamycin 1% and Benzoyl Peroxide 5%” NCT01015638

“Adapalene, benzoyl peroxideNCT02709902

NCT00776919

NCT01428466

NCT01106807

NCT00151541

NCT01132443

NCT00869492

NCT01052246

NCT03573115

NCT00663286

NCT02698436

NCT00558831

NCT01818167

NCT03650881

NCT02510144

NCT04548349

NCT00664248

NCT06336629

NCT02589405

NCT01044264

NCT05355844

NCT05676411

NCT02899000

NCT02515305

NCT00713609

NCT01796665

NCT00952523

NCT01742637

NCT01206348

NCT01504204

NCT02651220

NCT03563365

NCT01231334

NCT02005666

NCT00837213

NCT05675501

NCT03849885

NCT00787943

NCT02716090

NCT00624676

NCT01176955

NCT06673641

NCT01472900

NCT00687908

NCT04000347

NCT00877409

NCT01788384

NCT04021524

NCT02052752

NCT00926367

NCT01769235

NCT07032649

NCT00446043

NCT01260571

NCT00421993

NCT00377000

NCT02465632

NCT05096312

NCT03257202

NCT00658112

NCT00422240

NCT03122457

NCT02595034

NCT02578043

NCT01138514

NCT01422785

NCT05855629

NCT04028401

NCT01138735

NCT00964223

NCT00887484

NCT01448733

NCT00919191

NCT00964366

NCT00907257

NCT00907101

NCT01769664

NCT01209949

NCT02219776

NCT05536882

NCT04300010

NCT00671749

Known as Acetoxyl 2.5 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acetoxyl 5 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acnecide ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acnecide 10 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acnegel ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acnegel fte ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Acnidazil ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Anhydrous benzoyl peroxide ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benoxyl 10 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benoxyl 20 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benoxyl 5 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzagel 10 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzagel 5 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzamycin ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of acanya ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of aktipak ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of benzaclin ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of benzamycin ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of cabtreo ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of duac ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of epiduo ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of idp-126 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370
Known as Benzoyl peroxide component of onexton ChEMBL registry synonym — accepted as the source's own label CHEMBL1200370