drugset / Trial / NCT00907374
Low Dose Versus Aggressive Inhibition of the Renin-Angiotensin-Aldosterone (RAS) to Treat Microalbuminuria
RandomizedParallel-groupOpen-labelTreatment
Summary
The objective of the study is to assess the effect of standard versus aggressive inhibition of the renin-angiotensin system (RAS)in type 2 diabetic patients with microalbuminuria (MA) on; a)progression of microalbuminuria, b)estimated glomerular filtration rate (eGFR), c)endothelial dysfunction (measured by post-hyperemia arterial tonometry) and d)the slowing of the progression of atherosclerotic disease (measured by carotid intima media thickness \[CIMT\]).
Timeline
- Start
- 2005-07
- Primary completion
- 2009-04
- Completion
- 2009-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Benazepril | Unknown | 10 mg | Oral |
| Subject | Benazepril | Unknown | 40 mg | Oral |
| Subject | Benazepril | Unknown | 80 mg | Oral |
| Subject | Losartan | Other / unclassified | 25 mg | Oral |
| Subject | Losartan | Other / unclassified | 50 mg | Oral |
| Subject | Losartan | Other / unclassified | 100 mg | Oral |