Greater Occipital Nerve Block for Migraine Prophylaxis

Phase 4 Completed 70 enrolled Mayo Clinic National Center for Advancing Translational Sciences (NCATS) · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized, placebo-controlled trial documenting its effectiveness. Hypothesis: Greater occipital nerve block reduces the frequency of days with moderate or severe headache in patients with episodic or chronic migraine.

Timeline

Start: 2009-06
Primary completion: 2013-01
Completion: 2013-01

Outcome

Missed primary endpoint

paper Greater ONB does not reduce the frequency of moderate to severe migraine days in patients with episodic or chronic migraine compared to placebo. PMID 25505035 ↗

Publications

Dilli E, Halker R, Vargas B, Hentz J, Radam T, Rogers R, Dodick D. Occipital nerve block for the short-term preventive treatment of migraine: A randomized, double-blinded, placebo-controlled study. Cephalalgia. 2015 Oct;35(11):959-68. doi: 10.1177/0333102414561872. Epub 2014 Dec 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivicaine	Other / unclassified	0.5 %	Other
Subject	Bupivicaine	Other / unclassified	2.5 ml	Other
Subject	Methylprednisolone	Other / unclassified	0.5 ml	Other
Subject	Methylprednisolone	Other / unclassified	20 mg	Other
Comparator	Lidocaine	Other / unclassified	0.25 ml	Other
Comparator	Lidocaine	Other / unclassified	1 %	Other