Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone

Phase 4 Completed 218 enrolled Xiao-Ming Mao

RandomizedParallel-groupOpen-labelTreatment

Summary

Antithyroid drugs are widely used in treatment of Graves' disease (GD), but after therapy withdrawal, relapse rate is very high. The aim this trail is to evaluate the effects of intrathyroid injection of dexamethasone combined with antithyroid drugs on patients with newly diagnosed GD.

Timeline

Start: 2004-06
Primary completion: 2008-12
Completion: 2009-03

Outcome

Met primary endpoint

paper Seven patients (7.4%) experienced a relapse of overt hyperthyroidism in the MMI+IID group and 49 patients (51%) in MMI group during the 2-yr follow-up period (P < 0.001). PMID 19850691 ↗

Publications

Mao XM, Li HQ, Li Q, Li DM, Xie XJ, Yin GP, Zhang P, Xu XH, Wu JD, Chen SW, Wang SK. Prevention of relapse of Graves' disease by treatment with an intrathyroid injection of dexamethasone. J Clin Endocrinol Metab. 2009 Dec;94(12):4984-91. doi: 10.1210/jc.2009-1252. Epub 2009 Oct 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	5 mg	Other
Background	Methimazole	Small molecule	20 mg	—