drugset / Trial / NCT00918320
Studies of Temozolomide in Combination With Topotecan in Refractory and Relapsed Paediatric Solid Tumours
Phase 2
Completed
129 enrolled
Gustave Roussy, Cancer Campus, Grand Paris
Catholic University of the Sacred Heart · collabErasmus Medical Center · collabSt. Anna Kinderkrebsforschung · collab
NaSingle-groupOpen-labelTreatment
Summary
The purpose of the study is to determine whether the combination of Hycamtin (Topotecan) and Temozolomide is effective in the treatment of relapsed and refractory neuroblastoma and other paediatric solid tumors.
Timeline
- Start
- 2009-06
- Primary completion
- 2013-10
- Completion
- 2015-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Temozolomide | Small molecule | 150 mg/m2 | Oral |
| Subject | Topotecan | Small molecule | 0.75 mg/m2 | Intravenous |