Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production

Phase 4 Completed 7 enrolled Ullevaal University Hospital University of Oslo · collab

Non-randomizedCrossoverOpen-labelBasic science

Summary

The purpose of this study is to determine whether paracetamol, ibuprofen or their combination can modify generation of radical oxygen species (ROS) from stimulated neutrophils.

Timeline

Start: 2009-05
Primary completion: 2010-01
Completion: 2010-01

Publications

Background Stritesky Larssen K, Lyberg T. Oxidative status--age- and circadian variations?--a study in leukocytes/plasma. Neuro Endocrinol Lett. 2006 Aug;27(4):445-52.
Background Nagata M. Inflammatory cells and oxygen radicals. Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):503-4. doi: 10.2174/1568010054526322.
Background Nielsen VG, Webster RO. Inhibition of human polymorphonuclear leukocyte functions by ibuprofen. Immunopharmacology. 1987 Feb;13(1):61-71. doi: 10.1016/0162-3109(87)90027-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	1000 mg	Oral
Comparator	Ibuprofen	Small molecule	400 mg	Oral
Comparator	Ibuprofen	Small molecule	1200 mg	Oral

Indications

No indication recorded.