Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Completed 120 enrolled University of Zurich

RandomizedParallel-groupOpen-labelTreatment

Summary

Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Timeline

Start: 2007-10
Primary completion: 2009-11
Completion: 2009-12

Outcome

Met primary endpoint

paper troponin T as the most sensitive marker for myocardial injury at POD1 was significantly lower in the sevoflurane group compared with the propofol group PMID 23062276 ↗

paper unadjusted difference, -0.4; 95% CI, -0.7 to -0.1; P < 0.01 PMID 23062276 ↗

Publications

Steurer MP, Steurer MA, Baulig W, Piegeler T, Schlapfer M, Spahn DR, Falk V, Dreessen P, Theusinger OM, Schmid ER, Schwartz D, Neff TA, Beck-Schimmer B. Late pharmacologic conditioning with volatile anesthetics after cardiac surgery. Crit Care. 2012 Oct 14;16(5):R191. doi: 10.1186/cc11676.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	—	—
Subject	Sevoflurane	Other / unclassified	—	—

Indications

No indication recorded.