drugset / Trial / NCT00925535
Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061)
RandomizedCrossoverOpen-labelTreatment
Summary
Approximately 1/3 of persons living with HIV infection are co-infected with tuberculosis (TB). Rifabutin, used in the treatment of TB, is an inducer of drug metabolism thus may decrease concentrations of lersivirine if co-administered. Lersivirine is a modest inducer of drug metabolism, thus lersivirine may decrease concentrations of rifabutin as well.
Timeline
- Start
- 2010-05
- Primary completion
- 2010-08
- Completion
- 2010-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lersivirine | Small molecule | 1000 mg | — |
| Subject | Rifabutin | Small molecule | 300 mg | — |
Indications
No indication recorded.