Iloprost in High Risk Cardiac Surgical Patients

Summary

In this study effects of the intra operative, prophylactic inhalation of Iloprost (Ventavis) before and during extracorporal circulation on perioperative morbidity and outcome in high risk cardiac surgical patients is investigated in comparison to placebo.

Timeline

Start

2009-06

Primary completion

2012-03

Completion

2012-03

Outcome

Missed primary endpoint

paper Iloprost had no significant effect on the median [interquartile range] duration of postoperative ventilation compared with placebo PMID 30756339 ↗

Publications

• Winterhalter M, Rex S, Stoppe C, Kienbaum P, Muller HH, Kaufmann I, Kuppe H, Dongas A, Zwissler B; ILOCARD Investigators. Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD). Can J Anaesth. 2019 Aug;66(8):907-920. doi: 10.1007/s12630-019-01309-8. Epub 2019 Feb 12.

Drugs

Indications