drugset / Trial / NCT00931073
A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers
Non-randomizedCrossoverOpen-label
Summary
This study will evaluate the potential for a drug-drug interaction of Dimebon with ketoconazole and omeprazole, potent inhibitors of the drug metabolizing enzymes CYP3A4 and CYP2C19, respectively.
Timeline
- Start
- 2009-07
- Primary completion
- 2009-10
- Completion
- 2009-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketoconazole | Small molecule | 400 mg | — |
| Subject | Latrepirdine | Small molecule | 10 mg | Oral |
| Subject | Omeprazole | Other / unclassified | 40 mg | — |