Efficacy/Safety of Amlodipine Plus Losartan Versus Losartan in Patients With Essential Hypertension

Summary

The purpose of this study is to evaluate of efficacy and safety of amlodipine plus losartan and losartan alone in patients with essential hypertension inadequately controlled on losartan monotherapy.

Timeline

Start

2008-04

Primary completion

2008-11

Completion

2008-11

Outcome

Met primary endpoint

paper the amlodipine/losartan 5 mg/100 mg combination group achieved significantly greater reductions in SBP at week 8 PMID 22462558 ↗

paper Response rates were significantly higher in the amlodipine/losartan 5 mg/100 mg group versus the losartan 100 mg group PMID 22462558 ↗

Publications

• Hong BK, Park CG, Kim KS, Yoon MH, Yoon HJ, Yoon JH, Yang JY, Choi YJ, Cho SY. Comparison of the efficacy and safety of fixed-dose amlodipine/losartan and losartan in hypertensive patients inadequately controlled with losartan: a randomized, double-blind, multicenter study. Am J Cardiovasc Drugs. 2012 Jun 1;12(3):189-95. doi: 10.2165/11597410-000000000-00000.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amlodipine	Other / unclassified	5 mg	—
Comparator	Losartan	Other / unclassified	100 mg	—

Indications