Efficacy of IV Palo With IV Dexamethasone vs IV Palo for Prevention of Immediate & Delayed PONV

Phase 4 Completed 118 enrolled NYU Langone Health Eisai Inc. · collab

RandomizedParallel-groupQuadruple-blindSupportive care

Summary

The purpose of this study is to determine if subjects who receive Palonosetron plus Dexamethasone have less post-operative nausea and vomiting (PONV) than those who receive Palonosetron alone.

Timeline

Start: 2009-07
Primary completion: 2010-07
Completion: 2011-04

Publications

Results Blitz JD, Haile M, Kline R, Franco L, Didehvar S, Pachter HL, Newman E, Bekker A. A randomized double blind study to evaluate efficacy of palonosetron with dexamethasone versus palonosetron alone for prevention of postoperative and postdischarge nausea and vomiting in subjects undergoing laparoscopic surgeries with high emetogenic risk. Am J Ther. 2012 Sep;19(5):324-9. doi: 10.1097/MJT.0b013e318209dff1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	8 mg	Intravenous
Comparator	Palonosetron	Other / unclassified	0.075 mg	Intravenous

Indications

No indication recorded.