Prevention of Perioperative Acute Renal Failure

NCT00953940 ↗

Phase 4 Terminated 600 enrolled Hospital Universitario Ramon y Cajal Fondo de Investigacion Sanitaria · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

The purpose of this study is to measure the acute renal dysfunction on the first, second, seventh and twentieth days.

Timeline

Start: 2005-06
Primary completion: 2011-02
Completion: 2011-05

Outcome

Missed primary endpoint

Stopped: “An external board recommended to close the study for futility after the interin analysis”

paper Intravenous hydration with 0.9% normal saline before major open abdominal surgery was not effective in preventing postoperative AKI. PMID 26825017 ↗

Publications

Serrano AB, Candela-Toha AM, Zamora J, Vera J, Muriel A, Del Rey JM, Liano F. Preoperative hydration with 0.9% normal saline to prevent acute kidney injury after major elective open abdominal surgery: A randomised controlled trial. Eur J Anaesthesiol. 2016 Jun;33(6):436-43. doi: 10.1097/EJA.0000000000000421.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium chloride	Unknown	1.5 ml	Intravenous

Indications

No indication recorded.