Glucose Insulin Potassium With Intensive Insulin Therapy and (GIK2) Versus GIK Alone

Phase 3 Completed 772 enrolled University of Monastir

RandomizedParallel-groupSingle-blindTreatment

Summary

The aim of this study is to evaluate the effect of the glucose insulin potassium (GIK) infusion associated with intensive insulin therapy compared to GIK alone and control group in patients presenting to the ED with acute coronary syndrome.

Timeline

Start: 2010-08
Primary completion: 2013-12
Completion: 2014-06

Outcome

Met primary endpoint

paper the difference was significant between the GIK2 and control groups (P=0.01). PMID 29138181 ↗

Publications

Bouida W, Beltaief K, Msolli MA, Bzeouich N, Sekma A, Echeikh M, Mzali M, Boubaker H, Grissa MH, Boukef R, Hassine M, Dridi Z, Belguith A, Najjar F, Khochtali I, Nouira S; GREAT Network. One-Year Outcome of Intensive Insulin Therapy Combined to Glucose-Insulin-Potassium in Acute Coronary Syndrome: A Randomized Controlled Study. J Am Heart Assoc. 2017 Nov 14;6(11):e006674. doi: 10.1161/JAHA.117.006674.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Insulin	Protein / enzyme biologic	20 iu	Intravenous
Background	Glucose	Unknown	10 %	—
Background	Glucose	Unknown	1000 ml	—
Background	Potassium	Small molecule	70 meq	—