Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease

NCT00982072 ↗

Phase 4 Completed 52 enrolled Imperial College Healthcare NHS Trust

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare the effectiveness of tacrolimus (prograf) versus prednisolone for the treatment of nephrotic syndrome secondary to minimal change disease.

Timeline

Start: 2009-12
Primary completion: 2019-10-10
Completion: 2019-10-10

Outcome

Missed primary endpoint

registry analysis (other test); Prednisolone vs Tacrolimus; p = 0.12; Fisher Exact NCT00982072 ↗

Publications

Azukaitis K, Palmer SC, Strippoli GF, Hodson EM. Interventions for minimal change disease in adults with nephrotic syndrome. Cochrane Database Syst Rev. 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Prednisolone	Other / unclassified	1 mg/kg	Oral
Subject	Tacrolimus	Small molecule	0.05 mg/kg	Oral